Hussey A J, Howie J, Allan L G, Drummond G, Hayes J D, Beckett G J
Clin Chim Acta. 1986 Nov 30;161(1):19-28. doi: 10.1016/0009-8981(86)90259-7.
The measurement of plasma glutathione S-transferase (GST) concentrations have been used to assess the changes in hepatocellular integrity which occur following general anaesthesia. Of 20 selected patients, who received halothane for minor urological procedures, 16 showed a small transient rise in GST between 1 h and 3 h after anaesthesia. Similar changes were also observed in 8 consecutive patients who received halothane for various operative procedures. In 3 of these 28 patients a marked secondary rise in plasma GST was observed 24 h after anaesthesia. No significant changes in ALT were observed in either of the groups of patients. These data indicate two possible phases of hepatotoxicity following halothane administration which results in a transient impairment in hepatocellular integrity in the majority of patients who undergo anaesthesia with this agent.
血浆谷胱甘肽S-转移酶（GST）浓度的测量已被用于评估全身麻醉后发生的肝细胞完整性变化。在20名因小型泌尿外科手术接受氟烷治疗的选定患者中，16名患者在麻醉后1小时至3小时之间GST出现了小幅度的短暂升高。在8名因各种手术接受氟烷治疗的连续患者中也观察到了类似变化。在这28名患者中的3名患者中，麻醉后24小时观察到血浆GST出现明显的二次升高。两组患者的谷丙转氨酶（ALT）均未观察到显著变化。这些数据表明，氟烷给药后可能存在两个肝毒性阶段，这会导致大多数接受该药物麻醉的患者肝细胞完整性出现短暂损害。
