Translational Cancer Research Facility, National Center for Cancer Care and Research, Translational Research Institute, Hamad Medical Corporation, Doha, Qatar; College of Medicine, Qatar University, Doha, Qatar.
Translational Cancer Research Facility, National Center for Cancer Care and Research, Translational Research Institute, Hamad Medical Corporation, Doha, Qatar.
Life Sci. 2024 Feb 1;338:122390. doi: 10.1016/j.lfs.2023.122390. Epub 2023 Dec 30.
The correlation between chronic inflammation and cancer was initially identified in the 19th century. Biomolecules like interleukins, chemokines, tumor necrosis factors, growth factors, and adhesion molecules, which regulate inflammation, are recognized contributors to neoplastic transformation through various mechanisms, including oncogenic mutations, resistance to apoptosis, and adaptive responses like angiogenesis. This review aims to establish connections between the intricate and complex mechanisms of chronic inflammation and cancer. We illuminate implicit signaling mechanisms that drive the association between chronic inflammation and the initiation/progression of cancer, exploring potential impacts on other diseases. Additionally, we discuss the modalities of currently available therapeutic options for chronic inflammation and cancer, emphasizing the dual nature of such therapies. A thorough understanding of the molecular basis of chronic inflammation is crucial for developing novel approaches in the prevention and treatment of cancer.
慢性炎症与癌症之间的相关性最初是在 19 世纪被发现的。生物分子如白细胞介素、趋化因子、肿瘤坏死因子、生长因子和黏附分子，它们通过各种机制，如致癌突变、抗细胞凋亡以及血管生成等适应性反应，调节炎症，被认为是肿瘤转化的促成因素。本综述旨在建立慢性炎症和癌症之间复杂机制之间的联系。我们阐明了驱动慢性炎症与癌症发生/进展之间关联的隐含信号机制，探讨了其对其他疾病的潜在影响。此外，我们讨论了目前用于慢性炎症和癌症的治疗选择的方式，强调了这些疗法的双重性质。深入了解慢性炎症的分子基础对于开发癌症预防和治疗的新方法至关重要。
