Sugden A L, Bean B L, Straw J A
Clin Sci (Lond). 1987 Mar;72(3):321-7. doi: 10.1042/cs0720321.
These studies were designed to investigate the effects of high dietary K+ on electrolyte and water balance in young spontaneously hypertensive rats (SHR) and to relate these effects to changes in blood pressure. The high K+ diet reduced blood pressure by approximately 10 mmHg during the development of hypertension. Blood pressure, however, plateaued at the same maximum level as control by age 13 weeks. Rats fed the high K+ diet showed a significant increase in water intake and urine volume throughout the treatment period but no change in plasma volume or extracellular fluid volume occurred. A slight natriuresis was also observed in rats on the high K+ diet, but this was not of sufficient magnitude to decrease total body Na+. These results confirm previous findings that K+ causes a diuresis and a natriuresis, but demonstrate that the diuretic action of K+ cannot explain its antihypertensive properties in young SHR.
这些研究旨在调查高钾饮食对年轻自发性高血压大鼠（SHR）电解质和水平衡的影响，并将这些影响与血压变化联系起来。在高血压发展过程中，高钾饮食使血压降低了约10 mmHg。然而，到13周龄时，血压稳定在与对照组相同的最高水平。在整个治疗期间，喂食高钾饮食的大鼠水摄入量和尿量显著增加，但血浆容量或细胞外液容量没有变化。在高钾饮食的大鼠中也观察到轻微的利钠作用，但这一作用的程度不足以降低全身钠含量。这些结果证实了之前的发现，即钾会导致利尿和利钠，但表明钾的利尿作用无法解释其在年轻SHR中的降压特性。
