Sugden A L, Straw J A, Bean B L
Clin Sci (Lond). 1987 Mar;72(3):313-9. doi: 10.1042/cs0720313.
Blood pressure was measured after treatment with a high K+, a low Na+ and a combined high K+/low Na+ diet in young spontaneously hypertensive rats (SHR). A high K+ diet reduced blood pressure by approximately 10 mmHg during the development of hypertension. This decrease was accompanied by a significant increase in water intake and urine volume and a significant decrease in plasma renin activity (PRA). A low Na+ diet also decreased blood pressure significantly, but, in contrast to the high K+ diet, water intake and urine volume significantly decreased and PRA increased. When both diets were given together, the antihypertensive effects of both were eliminated. Thus while an increase in dietary K+ and a decrease in dietary Na+ are both effective antihypertensive regimens in SHR, the mechanism of action of each appears to be different and may be antagonistic in these animals.
在年轻的自发性高血压大鼠（SHR）中，用高钾、低钠以及高钾/低钠联合饮食进行治疗后测量血压。在高血压发展过程中，高钾饮食使血压降低约10 mmHg。这种降低伴随着水摄入量和尿量的显著增加以及血浆肾素活性（PRA）的显著降低。低钠饮食也显著降低了血压，但与高钾饮食相反，水摄入量和尿量显著减少而PRA增加。当两种饮食一起给予时，两者的降压作用都被消除。因此，虽然饮食中钾的增加和钠的减少在SHR中都是有效的降压方案，但每种方案的作用机制似乎不同，并且在这些动物中可能具有拮抗作用。
