Savaga A, Tribe C R
J Pathol. 1979 Apr;127(4):199-205. doi: 10.1002/path.1711270407.
We describe a method of inducing experimental amyloidosis in mice using injections of Candida albicans. Both viable and non-viable Candida produced amyloid and we compare the results with each method. Diagnosis was by liver biopsy, a technique of value in assessing the natural history of the disease. Once the amyloid had been induced, the disease always progressed until the animals died of generalised amyloidosis. This experimental model should, therefore, be suitable to use in assessing the treatment of amyloidosis.
我们描述了一种通过注射白色念珠菌在小鼠中诱导实验性淀粉样变性的方法。活的和死的白色念珠菌均可产生淀粉样蛋白，我们比较了两种方法的结果。通过肝脏活检进行诊断，这是一种评估该疾病自然病程的有价值的技术。一旦诱导出淀粉样变性，疾病总会进展，直至动物死于全身性淀粉样变性。因此，这个实验模型应该适用于评估淀粉样变性的治疗方法。
