Wohlgethan J R, Cathcart E S
J Immunol. 1981 Sep;127(3):1003-7.
A/J mice are highly resistant to induction of amyloidosis with serial injections of azocasein, compared to the CBA/J strain. (CBA X A) F2 hybrid mice were treated with azocasein, after spleen biopsy for assay of 3 immunologic functions differing in the parent strains. The proportions of amyloid susceptibility and resistance in the hybrid population conformed to the expectations for a single gene. Low responses to the T cell mitogen concanavalin A correlated with resistance to amyloid induction, whereas the response to lipopolysaccharide and the level of natural killer activity were independent of susceptibility to amyloidosis.
与CBA/J品系相比，A/J小鼠经连续注射偶氮酪蛋白诱导淀粉样变性的抗性很强。对（CBA×A）F2杂交小鼠进行脾脏活检以检测亲本品系中不同的3种免疫功能后，用偶氮酪蛋白对其进行处理。杂交群体中淀粉样变性易感性和抗性的比例符合单基因的预期。对T细胞有丝分裂原刀豆球蛋白A的低反应与淀粉样变性诱导抗性相关，而对脂多糖的反应和自然杀伤活性水平与淀粉样变性易感性无关。
