Rajendran Ratheesh, Antony S Delphine Priscilla, Ashik P Mohammed, Bharath Subin, Thomas Arun Jacob, Heboyan Artak
Department of Conservative Dentistry and Endodontics, Saveetha Dental college and hospitals, Saveetha institute of medical and technical sciences, Saveetha University, Chennai-77, TN, India.
KMCT Dental College, Kozhikode, KL, India.
SAGE Open Med. 2023 Dec 29;12:20503121231221634. doi: 10.1177/20503121231221634. eCollection 2024.
This study was intended to compare and determine the potency of strontium-doped nano-hydroxyapatite paste against a topical cream containing casein phosphopeptide-amorphous calcium phosphate and a regular dentifrice for remineralization of white spot lesions of enamel following orthodontic debonding.
Ninety individuals with white spot lesions on their enamel who visited the orthodontic department for de-bonding were selected for the research. Patients were randomly assigned to three distinct groups with each group consisting of 30 patients. Group 1 served as the control and received regular dentifrice, Group 2 received strontium-doped nano-hydroxyapatite paste, and Group 3 received casein phosphopeptide-amorphous calcium phosphate topical cream. Patients were instructed to locally apply a specified amount of the prescribed preparation twice daily for six weeks. The data were analysed using the statistical programme SPSS 22.0 (SPSS Inc., Chicago, IL, USA), and the level of significance had been set at < 0.05.
Group 1 did not show any change in the enamel following the application of toothpaste. Both Group 2 and 3 demonstrated higher post-treatment scores, indicating effective remineralization potential ( < 0.001). However, Group 2 (strontium-doped nano-hydroxyapatite paste) displayed significantly greater remineralization capacity when compared to group 3 (casein phosphopeptide-amorphous calcium phosphate topical cream).
Compared to conventional dentifrice and casein phosphopeptide-amorphous calcium phosphate paste, strontium-doped nano-hydroxyapatite preparation demonstrated greater enamel remineralization of the white spot lesions and favourable surface alterations in the enamel surface. strontium-doped nano-hydroxyapatite can be utilised safely and efficiently to treat early caries and remineralise white spot lesions on the enamel.
本研究旨在比较并确定掺锶纳米羟基磷灰石糊剂与含酪蛋白磷酸肽 - 无定形磷酸钙的外用乳膏及普通牙膏对正畸去粘结后牙釉质白斑病变再矿化的效力。
选取90名到正畸科进行去粘结且牙釉质有白斑病变的个体作为研究对象。患者被随机分为三组,每组30人。第1组作为对照组,使用普通牙膏;第2组使用掺锶纳米羟基磷灰石糊剂;第3组使用酪蛋白磷酸肽 - 无定形磷酸钙外用乳膏。患者被要求每天局部涂抹规定量的指定制剂两次,持续六周。使用统计软件SPSS 22.0(美国伊利诺伊州芝加哥市SPSS公司)对数据进行分析,显著性水平设定为<0.05。
第1组在使用牙膏后牙釉质未显示任何变化。第2组和第3组在治疗后均显示出更高的分数,表明具有有效的再矿化潜力(<0.001)。然而,与第3组(酪蛋白磷酸肽 - 无定形磷酸钙外用乳膏)相比,第2组(掺锶纳米羟基磷灰石糊剂)显示出显著更强的再矿化能力。
与传统牙膏和酪蛋白磷酸肽 - 无定形磷酸钙糊剂相比,掺锶纳米羟基磷灰石制剂对牙釉质白斑病变显示出更强的再矿化能力以及牙釉质表面更有利的表面改变。掺锶纳米羟基磷灰石可安全有效地用于治疗早期龋齿并使牙釉质上的白斑病变再矿化。