Jiang Fei, Wu Min, Li Rongpeng
Jiangsu Province Engineering Research Center of Cardiovascular Drugs Targeting Endothelial Cells, School of Life Sciences, Jiangsu Normal University, Xuzhou 221000, China.
Department of Laboratory Medicine, the Affiliated Hospital of Xuzhou Medical University, Xuzhou 221000, China.
Precis Clin Med. 2023 Dec 11;6(4):pbad031. doi: 10.1093/pcmedi/pbad031. eCollection 2023 Dec.
Inflammatory bowel diseases (IBD) are a group of chronic relapsing gastrointestinal inflammatory diseases with significant global incidence. Although the pathomechanism of IBD has been extensively investigated, several aspects of its pathogenesis remain unclear. Long non-coding RNAs (lncRNAs) are transcripts with more than 200 nucleotides in length that have potential protein-coding functions. LncRNAs play important roles in biological processes such as epigenetic modification, transcriptional regulation and post-transcriptional regulation. In this review, we summarize recent advances in research on IBD-related lncRNAs from the perspective of the overall intestinal microenvironment, as well as their potential roles as immune regulators, diagnostic biomarkers and therapeutic targets or agents for IBD.
炎症性肠病（IBD）是一组慢性复发性胃肠道炎症性疾病，在全球发病率颇高。尽管对IBD的发病机制已进行了广泛研究，但其发病机制的几个方面仍不清楚。长链非编码RNA（lncRNA）是长度超过200个核苷酸的转录本，具有潜在的蛋白质编码功能。lncRNA在表观遗传修饰、转录调控和转录后调控等生物学过程中发挥重要作用。在本综述中，我们从整体肠道微环境的角度总结了IBD相关lncRNA的研究进展，以及它们作为免疫调节剂、诊断生物标志物和IBD治疗靶点或药物的潜在作用。
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