Halberg F
Chronobiologia. 1986 Oct-Dec;13(4):355-8.
Chronobiology, aided by modern automatic instrumentation for the monitoring of marker rhythms and the administration of complex therapeutic schedules on the one hand and, on the other hand, by appropriate software for data analysis, exploits the organism's time-structure along several frequency scales. Available evidence shows that several modes of treatment, namely radiotherapy, chemotherapy and immunotherapy, can all be improved by timing. Even more important is the mapping of rhythms in health, for a comparison of rhythm characteristics between individuals at low or high risk with respect to a given disease; it may ultimately lead to a rational chronobiologic approach to cancer prevention.
时间生物学一方面借助现代自动仪器来监测标记节律并实施复杂的治疗方案，另一方面借助适当的数据分析软件，从多个频率尺度来探究机体的时间结构。现有证据表明，放疗、化疗和免疫疗法等多种治疗方式都可以通过选择合适的时间来得到改善。更重要的是绘制健康状态下的节律图谱，以便比较患某种特定疾病的低风险或高风险个体之间的节律特征；这最终可能会形成一种合理的癌症预防时间生物学方法。
