VCA Toronto Veterinary Emergency & Referral Hospital, 21 Rolark Drive, Scarborough, Ontario M1R 3B1 (Dooley); Animal Health Laboratory, University of Guelph, 419 Gordon Street, Guelph, Ontario N1G 2W1 (Stalker); Department of Clinical Studies, Ontario Veterinary College, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G 2W1 (Jensen, Pinard); Department of Oncology, Lakeshore Animal Health Partners, 806 Southdown Road, Mississauga, Ontario L5J 2Y4 (Pinard); Radiogenomics Laboratory, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5 (Pinard).
Can Vet J. 2024 Jan;65(1):25-28.
An 8-year-old spayed female British bulldog was presented with vomiting, hyporexia, and large-bowel diarrhea. Abdominal ultrasound revealed a focal colonic mass with an intussusception located immediately oral to the mass. The intussusception encompassed the ascending and transverse colon and was non-reducible. Colonic resection and anastomosis were completed to include the intussusception and colonic mass. Histopathological examination of the mass demonstrated a spindle cell neoplasm arising within the muscular wall of the intussuscepted segment that obliterated normal architecture. Mild-to-moderate cytoplasmic immunoreactivity of the tumor cell population for CD117 and smooth muscle actin was consistent with a diagnosis of a gastrointestinal stromal tumor. The dog described herein remains alive and free of progressive disease at the time of writing. Key clinical message: The entire gastrointestinal tract should be evaluated in any animal with gastrointestinal symptoms. A gastrointestinal stromal tumor remains a plausible differential diagnosis, regardless of the intestinal segment affected, and tumorassociated intussusception is a rare but urgent clinical finding.
一只 8 岁已绝育的雌性英国斗牛犬出现呕吐、食欲减退和大肠性腹泻。腹部超声显示结肠局部有一肿块，伴有位于肿块口侧的肠套叠。肠套叠包括升结肠和横结肠，且不可复位。进行结肠切除和吻合术以包括肠套叠和结肠肿块。肿块的组织病理学检查显示，在套叠段的肌壁内出现了一个梭形细胞肿瘤，使正常结构消失。肿瘤细胞群体对 CD117 和平滑肌肌动蛋白的细胞质免疫反应轻度至中度，符合胃肠道间质瘤的诊断。在撰写本文时，所描述的这只狗仍然存活且没有进行性疾病。关键临床信息：任何有胃肠道症状的动物都应评估整个胃肠道。胃肠道间质瘤仍然是一个合理的鉴别诊断，无论受影响的肠道节段如何，并且与肿瘤相关的肠套叠是一种罕见但紧急的临床发现。
