Chang Lili, Wang Chendi, Peng Jing, Song Yujie, Zhang Wanting, Chen Yurui, Peng Qiang, Li Xiulian, Liu Xuebo, Lan Ying
College of Food Science and Engineering, Northwest A&F University, Yangling 712100, Shaanxi, China.
School of Pharmacy, Binzhou Medical University, Yantai 264003, Shandong, China.
J Agric Food Chem. 2024 Jan 10;72(1):437-448. doi: 10.1021/acs.jafc.3c08462. Epub 2024 Jan 2.
Inflammatory bowel disease (IBD) is a chronic and recurrent disease. Increasing evidence suggests a higher incidence of depression in IBD patients compared with the general population, but the underlying mechanism remains uncertain. Rattan pepper polysaccharide (RPP) is an important active ingredient of rattan pepper, yet its effects and mechanisms on intestinal inflammation and depression-like behavior remain largely unknown. This study aims to investigate the ameliorating effect of RPP on dextran sulfate sodium salt (DSS)-induced intestinal inflammation and depression-like behavior as well as to reveal its mechanism. Our results indicate that RPP effectively ameliorated intestinal microbiota imbalance and metabolic disorders of short-chain fatty acids (SCFAs) and bile acids in mice with DSS-induced inflammation, contributing to the recovery of intestinal Th17/Treg homeostasis. Importantly, RPP effectively alleviated brain inflammation caused by intestinal inflammatory factors entering the brain through the blood-brain barrier. This effect may be attributed to the inhibition of the TLR4/NF-κB signaling pathway, which alleviates neuroinflammation, and the activation of the CREB/BDNF signaling pathway, which improves synaptic dysfunction. Therefore, our findings suggest that RPP may play a role in alleviating DSS-induced gut inflammation and depression-like behavior through the microbiota-gut-brain axis.
炎症性肠病（IBD）是一种慢性复发性疾病。越来越多的证据表明，与普通人群相比，IBD患者中抑郁症的发病率更高，但其潜在机制仍不确定。花椒多糖（RPP）是花椒的一种重要活性成分，但其对肠道炎症和抑郁样行为的影响及机制仍 largely unknown。本研究旨在探讨RPP对葡聚糖硫酸钠（DSS）诱导的肠道炎症和抑郁样行为的改善作用，并揭示其机制。我们的结果表明，RPP有效改善了DSS诱导炎症小鼠的肠道微生物群失衡以及短链脂肪酸（SCFAs）和胆汁酸的代谢紊乱，有助于肠道Th17/Treg稳态的恢复。重要的是，RPP有效减轻了肠道炎症因子通过血脑屏障进入大脑所引起的脑部炎症。这种作用可能归因于对TLR4/NF-κB信号通路的抑制，从而减轻神经炎症，以及对CREB/BDNF信号通路的激活，从而改善突触功能障碍。因此，我们的研究结果表明，RPP可能通过微生物-肠-脑轴在减轻DSS诱导的肠道炎症和抑郁样行为中发挥作用。
