Markowska A L, Olton D S
Department of Psychology, Johns Hopkins University, Baltimore, Maryland.
Int J Clin Pharmacol Res. 1990;10(1-2):65-8.
Acetyl-L-carnitine was given to aging rats to determine the extent to which it changed age-related impairments in several different behaviours. One group of rats was given acetyl-L-carnitine, 80 mg/day, beginning at 16 months of age. A second group of rats was housed and treated identically, except that no drug was administered. At 22 months of age, both groups of rats began a series of behavioural tests, along with a group of young rats, four months of age. The tests included: place learning on a circular platform, probe reversal of place learning on a circular platform, two choice simultaneous spatial discrimination in the stem of a T-maze spatial alternation in the arms of a T-maze, and sensory-motor behaviour (initiation of walking, turning in an alley, walking on a square, round, and rectangular bridge, turning on an inclined grid, holding on to a wire, light-dark preference). The tasks varied in their sensitivity to age-related impairments. These data indicate that long-term therapy with acetyl-L-carnitine attenuates certain age-related cognitive deficits and may have a beneficial effect on longevity.
给老龄大鼠服用乙酰左旋肉碱，以确定其对几种不同行为中与年龄相关的功能障碍的改善程度。一组大鼠从16个月大开始，每天服用80毫克乙酰左旋肉碱。另一组大鼠的饲养和处理方式相同，但不给予药物。在22个月大时，两组大鼠与一组4个月大的年轻大鼠一起开始了一系列行为测试。测试包括：在圆形平台上的位置学习、圆形平台上位置学习的探针反转、T型迷宫主干中的二选一同时空间辨别、T型迷宫臂中的空间交替以及感觉运动行为（开始行走、在小巷中转弯、在方形、圆形和矩形桥上行走、在倾斜网格上转弯、抓住电线、明暗偏好）。这些任务对与年龄相关的功能障碍的敏感性各不相同。这些数据表明，长期使用乙酰左旋肉碱治疗可减轻某些与年龄相关的认知缺陷，并且可能对寿命产生有益影响。
