Pancreatic Cancer Action Network, Manhattan Beach, CA.
Tempus, Chicago, IL.
JCO Clin Cancer Inform. 2024 Jan;8:e2300119. doi: 10.1200/CCI.23.00119.
Pancreatic cancer currently holds the position of third deadliest cancer in the United States and the 5-year survival rate is among the lowest for major cancers at just 12%. Thus, continued research efforts to better understand the clinical and molecular underpinnings of pancreatic cancer are critical to developing both early detection methodologies as well as improved therapeutic options. This study introduces Pancreatic Cancer Action Network's (PanCAN's) SPARK, a cloud-based data and analytics platform that integrates patient health data from the PanCAN's research initiatives and aims to accelerate pancreatic cancer research by making real-world patient health data and analysis tools easier to access and use.
The SPARK platform integrates clinical, molecular, multiomic, imaging, and patient-reported data generated from PanCAN's research initiatives. The platform is built on a cloud-based infrastructure powered by Velsera. Cohort exploration and browser capabilities are built using Velsera ARIA, a specialized product for leveraging clinicogenomic data to build cohorts, query variant information, and drive downstream association analyses. Data science and analytic capabilities are also built into the platform allowing researchers to perform simple to complex analysis.
Version 1 of the SPARK platform was released to pilot users, who represented diverse end users, including molecular biologists, clinicians, and bioinformaticians. Included in the pilot release of SPARK are deidentified clinical (including treatment and outcomes data), molecular, multiomic, and whole-slide pathology images for over 600 patients enrolled in PanCAN's Know Your Tumor molecular profiling service.
The pilot release of the SPARK platform introduces qualified researchers to PanCAN real-world patient health data and analytical resources in a centralized location.
目前，胰腺癌是美国第三大致死癌症，其 5 年生存率在主要癌症中最低，仅为 12%。因此，继续努力深入研究胰腺癌的临床和分子基础对于开发早期检测方法以及改善治疗选择至关重要。本研究介绍了胰腺癌行动网络（PanCAN）的 SPARK，这是一个基于云的数据和分析平台，它整合了 PanCAN 研究计划中的患者健康数据，旨在通过使真实世界的患者健康数据和分析工具更易于访问和使用，来加速胰腺癌研究。
SPARK 平台整合了来自 PanCAN 研究计划的临床、分子、多组学、成像和患者报告数据。该平台建立在由 Velsera 提供支持的基于云的基础设施上。使用 Velsera ARIA 构建了队列探索和浏览器功能，这是一种专门用于利用临床基因组数据构建队列、查询变异信息并推动下游关联分析的产品。还将数据科学和分析功能构建到平台中，允许研究人员执行简单到复杂的分析。
SPARK 平台的 1.0 版本已向试点用户发布，这些用户代表了不同的最终用户，包括分子生物学家、临床医生和生物信息学家。在 SPARK 的试点版本中，包含了超过 600 名参加 PanCAN 肿瘤分子分析服务的患者的去识别临床（包括治疗和结果数据）、分子、多组学和全幻灯片病理图像。
SPARK 平台的试点版本将合格的研究人员介绍给 PanCAN 的真实世界患者健康数据和集中的分析资源。
