精准肿瘤学的下一个前沿领域：蛋白质基因组学助力癌症诊断与治疗
The next horizon in precision oncology: Proteogenomics to inform cancer diagnosis and treatment.
作者信息
Rodriguez Henry, Zenklusen Jean Claude, Staudt Louis M, Doroshow James H, Lowy Douglas R
机构信息
Office of Cancer Clinical Proteomics Research, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Center for Cancer Genomics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
出版信息
Cell. 2021 Apr 1;184(7):1661-1670. doi: 10.1016/j.cell.2021.02.055.
Abstract
When it comes to precision oncology, proteogenomics may provide better prospects to the clinical characterization of tumors, help make a more accurate diagnosis of cancer, and improve treatment for patients with cancer. This perspective describes the significant contributions of The Cancer Genome Atlas and the Clinical Proteomic Tumor Analysis Consortium to precision oncology and makes the case that proteogenomics needs to be fully integrated into clinical trials and patient care in order for precision oncology to deliver the right cancer treatment to the right patient at the right dose and at the right time.
摘要
在精准肿瘤学方面，蛋白质基因组学可能为肿瘤的临床特征描述提供更好的前景，有助于更准确地诊断癌症，并改善癌症患者的治疗。这一观点阐述了癌症基因组图谱和临床蛋白质组肿瘤分析联盟对精准肿瘤学的重大贡献，并指出为了使精准肿瘤学能够在正确的时间以正确的剂量为正确的患者提供正确的癌症治疗，蛋白质基因组学需要全面融入临床试验和患者护理之中。
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