Laboratory of Autoimmune Diseases, Division of Rheumatology, Hospital de Clínicas de Porto Alegre, Centro de Pesquisas Experimentais, Universidade Federal Do Rio Grande Do Sul, Rua Ramiro Barcelos, 2350, Sala 12109, Porto Alegre, 90035‑003, Brazil.
Postgraduate Program in Medical Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Adv Rheumatol. 2024 Jan 2;64(1):2. doi: 10.1186/s42358-023-00344-w.
Systemic lupus erythematosus (SLE) is an autoimmune disease that can affect several organs and systems. The central and/or peripheral nervous system can suffer from complications known as neuropsychiatric lupus (NPSLE). Studies have associated the manifestations of SLE or NPSLE with vitamin D deficiency. It has been shown that hypovitaminosis D can lead to cognition deficits and cerebral hypoperfusion in patients with NPSLE. In this review article, we will address the main features related to vitamin D supplementation or serum vitamin D levels with neuropsychiatric manifestations, either in patients or in animal models of NPSLE.
系统性红斑狼疮（SLE）是一种自身免疫性疾病，可影响多个器官和系统。中枢和/或外周神经系统可能会受到称为神经精神狼疮（NPSLE）的并发症的影响。研究表明，SLE 或 NPSLE 的表现与维生素 D 缺乏有关。已经表明，维生素 D 缺乏症可导致 NPSLE 患者认知缺陷和脑灌注不足。在这篇综述文章中，我们将讨论与神经精神表现相关的维生素 D 补充或血清维生素 D 水平的主要特征，无论是在 NPSLE 患者还是动物模型中。
