Palaia Gaspare, Pernice Elena, Pergolini Daniele, Impellizzeri Alessandra, Migliau Guido, Gambarini Gianluca, Romeo Umberto, Polimeni Antonella
Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Via Caserta 6, 00161 Rome, Italy.
Pathogens. 2022 Jun 7;11(6):654. doi: 10.3390/pathogens11060654.
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a viral infection involving multi-organ manifestations. The main oral symptoms of COVID-19 associated are taste loss and xerostomia, but literature has reported other oral manifestation, such as oral blisters, ulcers, vesicles and other immunological lesions. This case report showed an Erythema Multiforme (EM) manifesting as oral mucosa lesions in a patient with a late diagnosis of COVID-19 infection. : A 30 years-old Caucasian woman was sent to an oral medicine office, in order to manage painful and oral mucosa lesions associated with target symmetrical skin lesions. Oral examination revealed extensive ulcers in the mouth and crusts on the lips. Based on clinical examinations, a diagnosis of Erythema Multiforme major was made and a drug therapy with steroids was administered. Five days after the specialist visit, the patient discovered that she was positive for COVID-19. The complete recovery occurred in 3 weeks. : Confirming the literature studies, EM is an early disease associated with COVID-19 infection.
2019冠状病毒病（COVID-19）由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起，是一种涉及多器官表现的病毒感染。COVID-19相关的主要口腔症状是味觉丧失和口干，但文献报道了其他口腔表现，如口腔水疱、溃疡、小水疱和其他免疫性病变。本病例报告显示一名COVID-19感染晚期患者出现多形红斑（EM），表现为口腔黏膜病变。一名30岁的白人女性被送往口腔内科，以处理与对称性靶形皮肤病变相关的口腔疼痛和黏膜病变。口腔检查发现口腔内有广泛溃疡，嘴唇有结痂。根据临床检查，诊断为重症多形红斑，并给予类固醇药物治疗。专科就诊五天后，患者发现自己COVID-19检测呈阳性。3周后完全康复。正如文献研究证实的那样，EM是一种与COVID-19感染相关的早期疾病。
