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缩小法布里-珀罗聚合物膜声学传感器的尺寸,用于光声内窥镜。

Scaling down the dimensions of a Fabry-Perot polymer film acoustic sensor for photoacoustic endoscopy.

机构信息

University of Michigan, Department of Mechanical Engineering, Ann Arbor, Michigan, United States.

University of Michigan, Division of Integrative Systems and Design, Ann Arbor, Michigan, United States.

出版信息

J Biomed Opt. 2024 Jan;29(Suppl 1):S11514. doi: 10.1117/1.JBO.29.S1.S11514. Epub 2024 Jan 2.

Abstract

SIGNIFICANCE

A Fabry-Perot (FP) polymer film sensor can be used to detect acoustic waves in a photoacoustic endoscope (PAE) if the dimensions can be adequately scaled down in size. Current FP sensors have limitations in size, sensitivity, and array configurability.

AIM

We aim to characterize and demonstrate the imaging performance of a miniature FP sensor to evaluate the effects of reduced size and finite dimensions.

APPROACH

A transfer matrix model was developed to characterize the frequency response of a multilayer miniature FP sensor. An analytical model was derived to describe the effects of a substrate with finite thickness. Finite-element analysis was performed to characterize the temporal response of a sensor with finite dimensions. Miniature FP sensors were designed and fabricated using gold films as reflective mirrors on either side of a parylene C film deposited on a glass wafer. A single-wavelength laser was used to interrogate the sensor using illumination delivered by fiber subprobes. Imaging phantoms were used to verify FP sensor performance, and images of blood vessels were collected from a live mouse.

RESULTS

The finite thickness substrate of the FP sensor resulted in echoes in the time domain signal that could be removed by back filtering. The substrate acted as a filter in the frequency domain. The finite lateral sensor dimensions produced side waves that could be eliminated by surface averaging using an interrogation beam with adequate diameter. The fabricated FP sensor produced a noise-equivalent pressure = 0.76 kPa, bandwidth of 16.6 MHz, a spectral full-width at-half-maximum = 0.2886 nm, and quality factor . Photoacoustic images were collected from phantoms and blood vessels in a live mouse.

CONCLUSIONS

A miniature wafer-based FP sensor design has been demonstrated with scaled down form factor for future use in PAE.

摘要

意义

如果尺寸能够充分缩小,法布里-珀罗(FP)聚合物膜传感器可用于检测光声内窥镜(PAE)中的声波。目前的 FP 传感器在尺寸、灵敏度和阵列可配置性方面存在局限性。

目的

我们旨在表征和演示微型 FP 传感器的成像性能,以评估尺寸减小和有限尺寸的影响。

方法

开发了传递矩阵模型来表征多层微型 FP 传感器的频率响应。推导出一个解析模型来描述具有有限厚度的基底的影响。进行有限元分析以表征具有有限尺寸的传感器的时间响应。使用金膜作为反射镜在沉积在玻璃晶片上的聚对二甲苯 C 膜的两侧设计和制造微型 FP 传感器。使用单波长激光通过光纤子探头提供的照明来询问传感器。使用成像体模验证 FP 传感器性能,并从活体小鼠收集血管图像。

结果

FP 传感器的有限厚度基底在时域信号中产生回波,这些回波可以通过后向滤波去除。基底在频域中起滤波器的作用。有限的横向传感器尺寸产生的边波可以通过使用具有足够直径的询问光束进行表面平均来消除。制造的 FP 传感器产生的噪声等效压力 = 0.76 kPa,带宽为 16.6 MHz,光谱全宽半最大值 = 0.2886 nm,品质因数 Q = 125。从活体小鼠的体模和血管中采集了光声图像。

结论

已经展示了一种微型基于晶圆的 FP 传感器设计,其缩小了外形尺寸,可用于未来的 PAE。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7429/10760494/c751f54d95db/JBO-029-S11514-g001.jpg

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