School of Physical Education, Shaanxi Normal University, Xi'an, China.
Southwest University, Chongqing, China.
Front Public Health. 2023 Dec 19;11:1243213. doi: 10.3389/fpubh.2023.1243213. eCollection 2023.
A meta-analysis was conducted to examine the differences in heart rate variability (HRV) between depressed patients and healthy individuals, with the purpose of providing a theoretical basis for the diagnosis of depression and the prevention of cardiovascular diseases.
To search China National Knowledge Infrastructure (CNKI), WanFang, VIP, PubMed, Web of Science, Science Direct, and Cochrane Library databases to collect case-control studies on HRV in depressed patients, the retrieval date is from the establishment of the database to December 2022. Effective Public Health Practice Project (EPHPP) scale was used to evaluate literature quality, and Stata14.0 software was used for meta-analysis.
This study comprised of 43 papers, 22 written in Chinese and 21 in English, that included 2,359 subjects in the depression group and 3,547 in the healthy control group. Meta-analysis results showed that compared with the healthy control group, patients with depression had lower SDNN [ = -0.87, (-1.14, -0.60), = -6.254, < 0.01], RMSSD [ = -0.51, (-0.69,-0.33), = -5.525, < 0.01], PNN50 [ = -0.43, (-0.59, -0.27), = -5.245, < 0.01], LF [ = -0.34, (-0.55, - 0.13), = -3.104, < 0.01], and HF [ = -0.51, (-0.69, -0.33), = -5.669 < 0.01], and LF/HF [ = -0.05, (-0.27, 0.18), = -0.410, = 0.682] showed no significant difference.
This research revealed that HRV measures of depressed individuals were lower than those of the healthy population, except for LF/HF, suggesting that people with depression may be more at risk of cardiovascular diseases than the healthy population.
进行荟萃分析，以检验抑郁患者和健康个体之间心率变异性（HRV）的差异，为抑郁症的诊断和心血管疾病的预防提供理论依据。
检索中国知网（CNKI）、万方、维普、PubMed、Web of Science、Science Direct 和 Cochrane Library 数据库，收集关于抑郁患者 HRV 的病例对照研究，检索日期为数据库建立至 2022 年 12 月。采用有效公共卫生实践项目（EPHPP）量表评价文献质量，采用 Stata14.0 软件进行荟萃分析。
本研究共纳入 43 篇文献，其中 22 篇为中文，21 篇为英文，包括抑郁组 2359 例，健康对照组 3547 例。荟萃分析结果显示，与健康对照组相比，抑郁患者的 SDNN[ = -0.87, (-1.14, -0.60)， = -6.254， < 0.01]、RMSSD[ = -0.51, (-0.69,-0.33)， = -5.525， < 0.01]、PNN50[ = -0.43, (-0.59, -0.27)， = -5.245， < 0.01]、LF[ = -0.34, (-0.55, -0.13)， = -3.104， < 0.01]和 HF[ = -0.51, (-0.69, -0.33)， = -5.669， < 0.01]较低，LF/HF[ = -0.05, (-0.27, 0.18)， = -0.410， = 0.682]差异无统计学意义。
本研究表明，与健康人群相比，抑郁患者的 HRV 指标较低，除 LF/HF 外，提示抑郁患者患心血管疾病的风险可能高于健康人群。
