Adachi Koichiro, Takizawa Ryu
Department of Clinical Psychology, Graduate School of Education, The University of Tokyo, Tokyo, Japan.
MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Stress Health. 2025 Aug;41(4):e70083. doi: 10.1002/smi.70083.
This study aimed to determine whether online-guided mindfulness-based interventions (MBIs) in daily life improve autonomic nervous system function as measured by the pupillary light reflex (PLR) in healthy subjects. A total of 94 university students were randomly allocated to either an intervention group or a waitlist control group. Participants practiced single-session meditation in a laboratory. During the intervention period, the participants practiced brief online mindfulness meditation for 12 weeks. PLR and psychological indices were measured before and after single and multiple mindfulness sessions. Using a multiple-regression analysis controlling for the baseline values, participants in the intervention group showed significantly decreased emotional fluctuations and significantly increased relaxation compared to those in the control group in a single session, whereas no significant differences in physiological indices were detected. In 12-week multiple sessions, participants in the intervention group showed significantly decreased state anxiety (p = 0.05), and marginally significantly decreased sympathetic nervous system activation (VD, p = 0.08) and perceived stress (p = 0.07) compared to those in the control group. These results suggest that the effects of mindfulness meditation on autonomic nerve function may be cumulative. These findings highlight the preventive effects of continuing online-guided MBIs in a healthy population and the potential usefulness of pupilometers in monitoring intervention effects. The applicability of pupillometry is further supported by the finding that MBIs improved psychological indices. Trial Registration: This study was not pre-registered.
本研究旨在确定日常生活中基于正念的在线引导干预措施（MBIs）是否能改善健康受试者的自主神经系统功能，该功能通过瞳孔对光反射（PLR）来衡量。共有94名大学生被随机分配到干预组或候补对照组。参与者在实验室进行单节冥想练习。在干预期内，参与者进行了为期12周的简短在线正念冥想。在单节和多节正念课程前后测量PLR和心理指标。通过控制基线值的多元回归分析，干预组参与者在单节课程中与对照组相比，情绪波动显著降低，放松程度显著提高，而生理指标未检测到显著差异。在为期12周的多节课程中，干预组参与者与对照组相比，状态焦虑显著降低（p = 0.05），交感神经系统激活（VD，p = 0.08）和感知压力（p = 0.07）略有显著降低。这些结果表明，正念冥想对自主神经功能的影响可能是累积性的。这些发现突出了持续进行基于正念的在线引导干预措施对健康人群的预防作用以及瞳孔测量仪在监测干预效果方面的潜在用途。MBIs改善心理指标这一发现进一步支持了瞳孔测量法的适用性。试验注册：本研究未预先注册。
