Costagliola C, Iuliano G, Menzione M, Rinaldi E, Vito P, Auricchio G
Exp Eye Res. 1986 Dec;43(6):905-14. doi: 10.1016/0014-4835(86)90069-2.
High doses of orally administered vitamin E have been given to humans, rabbits and rats. Placebo has been given to control groups. At the end of the treatment period, enhanced levels of reduced glutathione (GSH) were found in the red blood cells (humans and rabbits), aqueous humor (humans and rabbits) and lens (rabbits and rats) of treated subjects and animals. The percentage of GSH converted to oxidized glutathione (GSSG) was the same in both vitamin E-supplied and control groups. The GSSG--GSH ratio remained unchanged. The plasma levels of vitamin E were significantly higher in treated than in control subjects and animals. At the end of the study, the levels of vitamin E in aqueous humor and lens of rabbit were the same in animals which received vitamin E and in animals which received placebo. Lastly, vitamin E administration did not influence ascorbic-acid levels in plasma (humans and rabbits), aqueous humor, lens and vitreous body (rabbits).
已对人类、兔子和大鼠口服高剂量的维生素E。对照组则给予安慰剂。在治疗期结束时，发现接受治疗的受试者和动物的红细胞（人类和兔子）、房水（人类和兔子）以及晶状体（兔子和大鼠）中还原型谷胱甘肽（GSH）水平升高。在补充维生素E的组和对照组中，GSH转化为氧化型谷胱甘肽（GSSG）的百分比相同。GSSG与GSH的比值保持不变。治疗组受试者和动物的血浆维生素E水平显著高于对照组。在研究结束时，接受维生素E的兔子和接受安慰剂的兔子的房水和晶状体中的维生素E水平相同。最后，给予维生素E并未影响血浆（人类和兔子）、房水、晶状体和玻璃体（兔子）中的抗坏血酸水平。
