Huang Mao, Liu Yixuan, Yan Qijia, Peng Miao, Ge Junshang, Mo Yongzhen, Wang Yumin, Wang Fuyan, Zeng Zhaoyang, Li Yong, Fan Chunmei, Xiong Wei
NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Affiliated Cancer Hospital of Xiangya School of Medicine, Hunan Cancer Hospital, Central South University, Changsha, China.
Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China.
Cell Oncol (Dordr). 2024 Jun;47(3):733-757. doi: 10.1007/s13402-023-00909-3. Epub 2024 Jan 3.
Natural killer (NK) cells have gained considerable attention and hold great potential for their application in tumor immunotherapy. This is mainly due to their MHC-unrestricted and pan-specific recognition capabilities, as well as their ability to rapidly respond to and eliminate target cells. To artificially generate therapeutic NK cells, various materials can be utilized, such as peripheral blood mononuclear cells (PBMCs), umbilical cord blood (UCB), induced pluripotent stem cells (iPSCs), and NK cell lines. Exploiting the therapeutic potential of NK cells to treat tumors through in vivo and in vitro therapeutic modalities has yielded positive therapeutic results.
This review provides a comprehensive description of NK cell therapeutic approaches for tumors and discusses the current problems associated with these therapeutic approaches and the prospects of NK cell therapy for tumors.
自然杀伤（NK）细胞已受到广泛关注，并在肿瘤免疫治疗中具有巨大的应用潜力。这主要归因于其不受主要组织相容性复合体（MHC）限制的泛特异性识别能力，以及快速响应和消除靶细胞的能力。为了人工生成治疗性NK细胞，可以利用多种材料，如外周血单个核细胞（PBMC）、脐带血（UCB）、诱导多能干细胞（iPSC）和NK细胞系。通过体内和体外治疗方式利用NK细胞的治疗潜力已产生了积极的治疗效果。
本综述全面描述了NK细胞治疗肿瘤的方法，并讨论了这些治疗方法目前存在的问题以及NK细胞治疗肿瘤的前景。
