Kauffmann F, Neukirch F, Martin J P, Claude J R
Eur J Respir Dis. 1987 Feb;70(2):78-85.
In a working population of 912 men, aged 22 to 54 years, 8.3% reported a history of childhood respiratory illness before 16 years of age. Those reporting a history of bronchitis or pneumonia (BP) before 2 years of age had significantly lower FEV1 values than those who did not report such a history, whereas those reporting BP at a later age, or primary tuberculosis, did not have lower values. The observed association was unlikely to be due to preferential recall bias, since BP before 2 years of age was not associated with a higher reported prevalence of current respiratory symptoms of cough, phlegm, or dyspnea, and the observed association remained after exclusion of those with a history of wheezing or asthma. Furthermore, the relation remained significant after taking into account parental smoking, Pi phenotype and a history of eczema in childhood. These results suggest that BP before 2 years of age, a period of rapid alveolar multiplication, may be related to the occurrence of adult chronic air-flow limitation.
在912名年龄在22至54岁之间的在职男性中，8.3%的人报告在16岁之前有儿童期呼吸道疾病史。那些报告在2岁之前有支气管炎或肺炎（BP）病史的人，其第一秒用力呼气容积（FEV1）值显著低于未报告此类病史的人，而那些在较晚年龄报告BP或原发性肺结核的人，其FEV1值并不低。观察到的这种关联不太可能是由于优先回忆偏倚，因为2岁之前的BP与目前咳嗽、咳痰或呼吸困难等呼吸道症状的较高报告患病率无关，并且在排除有喘息或哮喘病史的人之后，观察到的这种关联仍然存在。此外，在考虑父母吸烟、Pi表型和儿童期湿疹病史后，这种关系仍然显著。这些结果表明，在2岁之前这个肺泡快速增殖的时期发生的BP，可能与成人慢性气流受限的发生有关。
