Bristol J B, Ghatei M A, Smith J H, Bloom S R, Williamson R C
Gastroenterology. 1987 Mar;92(3):617-24. doi: 10.1016/0016-5085(87)90009-6.
The effect of physiologic increases of plasma enteroglucagon, induced by massive bypass or resection of small bowel, on large bowel cell turnover and carcinogenesis was studied in rats in which the distal colon was isolated as a mucous fistula. After injections of azoxymethane, either 85% end-to-side jejunoileal bypass, 85% jejunoileal resection, or sham bypass was performed. Controls underwent colonic transection and resuture, azoxymethane treatment, and then sham bypass. Thirty weeks later the plasma enteroglucagon level had almost trebled after jejunoileal bypass (p less than 0.001) and almost doubled after jejunoileal resection (p less than 0.002) when compared with sham bypass; sham values did not differ from controls. The median number of tumors per rat in the distal (defunctioned) colon fell from 2 to 0 (p less than 0.05). Segmental weight fell by 45% (p less than 0.001) and crypt cell production rate by 75% (p less than 0.001). Neither tumor yield nor adaptation was affected by jejunoileal bypass or jejunoileal resection. Plasma enteroglucagon has no effect on colonic cell turnover or carcinogenesis in the absence of luminal content.
在将远端结肠作为黏液瘘分离的大鼠中，研究了小肠大面积旁路或切除所诱导的血浆肠高血糖素生理性增加对大肠细胞更新和致癌作用的影响。注射偶氮甲烷后，分别进行85%端侧空肠回肠旁路术、85%空肠回肠切除术或假旁路手术。对照组进行结肠横断和缝合、偶氮甲烷处理，然后进行假旁路手术。30周后，与假旁路手术相比，空肠回肠旁路术后血浆肠高血糖素水平几乎增加了两倍（p<0.001），空肠回肠切除术后几乎增加了一倍（p<0.002）；假手术组的值与对照组无差异。远端（失功能）结肠中每只大鼠的肿瘤中位数从2个降至0个（p<0.05）。节段重量下降了45%（p<0.001），隐窝细胞产生率下降了75%（p<0.001）。空肠回肠旁路术或空肠回肠切除术对肿瘤发生率和适应性均无影响。在没有管腔内容物的情况下，血浆肠高血糖素对结肠细胞更新或致癌作用没有影响。
