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坏疽性口炎是一种导致面部毁容的儿童疾病:来自埃塞俄比亚坏疽性口炎病例的见解。

Noma is a facial disfiguring childhood disease: Insights from cases of Noma in Ethiopia.

作者信息

Gebretsadik Heron Gezahegn

机构信息

School of Global Health & Bioethics, Euclid University, Banjul, Gambia.

出版信息

Int J Pediatr Otorhinolaryngol. 2024 Feb;177:111845. doi: 10.1016/j.ijporl.2023.111845. Epub 2024 Jan 1.

Abstract

OBJECTIVES

Noma is a neglected infectious disease that causes severe destruction of facial tissues and poses a significant public health threat. The disease reportedly affects individuals with a debilitating health condition. This study aimed to identify the most vulnerable age group affected by Noma disease and assess the severity of tissue damage among Noma cases in Ethiopia.

METHODS

A cross-sectional study was conducted to determine the age group most susceptible to noma and assess the disease-associated severity of tissue damage. The research objectives were met by scrutinizing electronic medical records of noma cases treated in Addis Ababa, Ethiopia, from 2007 to 2019, obtained from the Facing Africa database. Data collection was carried out using a standardized survey form, while the severity of facial tissue damage was assessed using the NOIPTUS score.

RESULTS

Among 164 Noma cases with documented data on disease onset, 92.7 % occurred during childhood, with 92.1 % of those cases being children aged ten years and younger. Approximately 11.6 % of all noma cases had mild tissue damage, classified as NOITULP grade 1, while 26.2 % had an intermediate level of tissue damage, classified as NOITULP grade 2. Severe tissue damage (NOITULP grade 3) was present in 37.2 % of cases, while 25 % had very severe tissue damage (NOITULP grade 4).

CONCLUSIONS

The findings underscore the vulnerability of children, particularly those aged ten years and younger, to Noma disease, supporting the argument that Noma is a facial-disfiguring childhood disease. Targeted interventions and preventive measures during childhood can be vital in controlling Noma incidence.

摘要

目的

坏疽性口炎是一种被忽视的传染病,可导致面部组织严重破坏,对公共卫生构成重大威胁。据报道,该疾病影响健康状况不佳的个体。本研究旨在确定受坏疽性口炎影响最脆弱的年龄组,并评估埃塞俄比亚坏疽性口炎病例的组织损伤严重程度。

方法

进行了一项横断面研究,以确定最易患坏疽性口炎的年龄组,并评估与疾病相关的组织损伤严重程度。通过审查2007年至2019年在埃塞俄比亚亚的斯亚贝巴接受治疗的坏疽性口炎病例的电子病历(从“面对非洲”数据库获取)实现了研究目标。使用标准化调查问卷进行数据收集,同时使用NOIPTUS评分评估面部组织损伤的严重程度。

结果

在164例有疾病发病记录数据的坏疽性口炎病例中,92.7%发生在儿童期,其中92.1%的病例为10岁及以下儿童。所有坏疽性口炎病例中约11.6%有轻度组织损伤,分类为NOITULP 1级,而26.2%有中度组织损伤,分类为NOITULP 2级。37.2%的病例有严重组织损伤(NOITULP 3级),而25%有非常严重的组织损伤(NOITULP 4级)。

结论

研究结果强调了儿童,特别是10岁及以下儿童,易患坏疽性口炎,支持了坏疽性口炎是一种导致面部毁容的儿童疾病这一观点。儿童期针对性的干预措施和预防措施对于控制坏疽性口炎发病率可能至关重要。

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