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[可溶性介质作为免疫反应中淋巴细胞间通讯手段（作者译）]

[Soluble mediators as a means of communication between lymphozytes in immune reactions (author's transl)].

作者信息

Wecker E, Schimpl A

出版信息

Klin Wochenschr. 1979 Jun 15;57(12):631-40. doi: 10.1007/BF01477630.

DOI:10.1007/BF01477630
PMID:381769
Abstract

Soluble mediators play an important role in the positive and negative regulation of immune reactions. This has been particularly well documented for T-B-cooperation in the humoral immune response to T-dependent antigens. T-helper cells produce a T-cell replacing Factor (TRF) upon mitogenic or antigenic stimulation. It provides the signal to antigen triggered B-cells to begin with active antibody synthesis and secretion and thus it is a positively regulating mediator. Additional functional and some structural characteristics of TRF are described. Antigen specific and non-specific suppressor factors seem to be involved in the negative regulation of immune responses. Thus, the communication between cells of the immune system is largely conducted via soluble signal substances.

摘要

可溶性介质在免疫反应的正负调节中发挥着重要作用。这在针对T细胞依赖性抗原的体液免疫反应中T细胞与B细胞的协作方面已有特别充分的记录。促有丝分裂或抗原刺激后，辅助性T细胞会产生一种T细胞替代因子（TRF）。它向抗原触发的B细胞提供信号，使其开始活跃的抗体合成与分泌，因此它是一种正向调节介质。文中还描述了TRF的其他功能及一些结构特征。抗原特异性和非特异性抑制因子似乎参与了免疫反应的负调节。因此，免疫系统细胞间的通讯很大程度上是通过可溶性信号物质进行的。

相似文献

1
[Soluble mediators as a means of communication between lymphozytes in immune reactions (author's transl)].[可溶性介质作为免疫反应中淋巴细胞间通讯手段（作者译）]
Klin Wochenschr. 1979 Jun 15;57(12):631-40. doi: 10.1007/BF01477630.
2
[Mechanism of action of T cell factors regulating antibody formation].[调节抗体形成的T细胞因子的作用机制]
C R Seances Soc Biol Fil. 1979;173(2):221-30.
3
Regulation of antibody synthesis to sheep red cells in cultures of nu/nu spleen cells by T-cell replacing factor (TRF) and immunoglobulin-binding factor (IBF).T细胞替代因子（TRF）和免疫球蛋白结合因子（IBF）对无胸腺裸鼠脾细胞培养物中针对绵羊红细胞的抗体合成的调节作用。
Ann Immunol (Paris). 1979 Sep-Oct;130C(5):711-20.
4
Obligatory role of gamma interferon in T cell-replacing factor-dependent, antigen-specific murine B cell responses.γ干扰素在依赖T细胞替代因子的抗原特异性小鼠B细胞应答中的必需作用。
J Exp Med. 1985 May 1;161(5):953-71. doi: 10.1084/jem.161.5.953.
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J Immunol. 1986 May 1;136(9):3335-40.
6
Analysis of T cell-replacing factor-like activity: potent induction of T helper activity for human B cells by residual concanavalin A and interleukin 2.T细胞替代因子样活性分析：残留伴刀豆球蛋白A和白细胞介素2对人B细胞T辅助活性的强力诱导
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Ann N Y Acad Sci. 1975 Feb 28;249:258-63. doi: 10.1111/j.1749-6632.1975.tb29073.x.
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[The immune system: hormones and mediators].
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The effects of mitogen-stimulated T cells on the response of B cell to antigen and the mechanism of T cell stimulation and of the B cell response.丝裂原刺激的T细胞对B细胞对抗原反应的影响以及T细胞刺激和B细胞反应的机制。
Soc Gen Physiol Ser. 1974;29:199-215.

本文引用的文献

1
Immunization of dissociated spleen cell cultures from normal mice.对来自正常小鼠的脾细胞解离培养物进行免疫接种。
J Exp Med. 1967 Sep 1;126(3):423-42. doi: 10.1084/jem.126.3.423.
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Cell interactions in the immune response in vitro. IV. Comparison of the effects of antigen-specific and allogeneic thymus-derived cell factors.体外免疫应答中的细胞相互作用。IV. 抗原特异性和同种异体胸腺衍生细胞因子作用的比较。
J Exp Med. 1972 Oct 1;136(4):722-36. doi: 10.1084/jem.136.4.722.
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Removal of specific cooperative T cell factor by anti-H-2 but not by anti-Ig sera.
通过抗H-2血清而非抗Ig血清去除特异性协同T细胞因子。
Nature. 1974 Sep 6;251(5470):63-5. doi: 10.1038/251063a0.
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Replacement of T-cell function by a T-cell product.用一种T细胞产物替代T细胞功能。
Nat New Biol. 1972 May 3;237(70):15-7. doi: 10.1038/newbio237015a0.
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A third signal in B cell activation given by TRF.由TRF提供的B细胞激活中的第三种信号。
Transplant Rev. 1975;23:176-88. doi: 10.1111/j.1600-065x.1975.tb00157.x.
6
A T-cell -produced mediator substance active in the humoral immune response.一种在体液免疫反应中具有活性的T细胞产生的介质物质。
Ann N Y Acad Sci. 1975 Feb 28;249:258-63. doi: 10.1111/j.1749-6632.1975.tb29073.x.
7
Mechanism of T-cell help in the immune response to soluble protein antigens II. Reconstitution of primary and secondary in vitro immune responses to dinitrophenyl-carrier conjugates by T-cell-replacing factor.T细胞辅助可溶性蛋白抗原免疫应答的机制II. 用T细胞替代因子重建对二硝基苯基-载体偶联物的初次和二次体外免疫应答
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Mechanism of T-cell help in the immune response to soluble protein antigens. I. Evidence for in situ generation and action of T-cell-replacing factor during the anamnestic response to dinitrophenyl keyhole limpet hemocyanin in vitro.T细胞在针对可溶性蛋白抗原的免疫应答中的辅助机制。I. 体外对二硝基苯基钥孔戚血蓝蛋白进行回忆应答期间T细胞替代因子原位生成及作用的证据。
J Exp Med. 1977 May 1;145(5):1216-27. doi: 10.1084/jem.145.5.1216.
9
Specific suppressive factors produced by hybridomas derived from the fusion of enriched suppressor T cells and a T lymphoma cell line.由富集的抑制性T细胞与一种T淋巴瘤细胞系融合产生的杂交瘤所产生的特异性抑制因子。
J Exp Med. 1978 Aug 1;148(2):373-82. doi: 10.1084/jem.148.2.373.
10
T-cell lines producing antigen-specific suppressor factor.产生抗原特异性抑制因子的T细胞系
Nature. 1978 Aug 3;274(5670):477-80. doi: 10.1038/274477a0.