T细胞辅助可溶性蛋白抗原免疫应答的机制II. 用T细胞替代因子重建对二硝基苯基-载体偶联物的初次和二次体外免疫应答
Mechanism of T-cell help in the immune response to soluble protein antigens II. Reconstitution of primary and secondary in vitro immune responses to dinitrophenyl-carrier conjugates by T-cell-replacing factor.
作者信息
Hünig T H, Schimpl A, Wecker E
出版信息
J Exp Med. 1977 May 1;145(5):1228-36. doi: 10.1084/jem.145.5.1228.
Abstract
Spleen cells of dinitrophenyl keyhole limpet hemocyanin (DNPKLH) primed and boosted mice produced a nonantigen-specific helper factor upon in vitro challenge with DNPKLH. This helper factor displays all of the biological characteristics so far described for TRF produced by allogeneic or Concanavalin A stimulation of mouse spleen cells. It restores the primary anti-SRBC response in nude spleen cultures following the same kinetics of action as T-cell-replacing factor (TRF). Conversely, TRF restores the primary in vitro immune response of nude spleen cultures to DNPKLH. TRF also restores the secondary anti-hapten IgG response of T-cell-deprived spleen cell cultures derived from DNPKLH primed and boosted mice. Here the need for carrier specificity is fully overcome. The data therefore suggest that TRF, as a nonantigen-specific maturation signal, is involved in the primary and secondary immune responses to both particulate and soluble antigens.
摘要
用二硝基苯基钥孔戚血蓝蛋白（DNPKLH）致敏并加强免疫的小鼠的脾细胞，在体外用DNPKLH攻击时产生了一种非抗原特异性辅助因子。这种辅助因子表现出了迄今所描述的由同种异体或刀豆球蛋白A刺激小鼠脾细胞产生的转移因子（TRF）的所有生物学特性。它能在裸脾培养物中恢复初次抗绵羊红细胞（SRBC）反应，其作用动力学与T细胞替代因子（TRF）相同。相反，TRF能恢复裸脾培养物对DNPKLH的体外初次免疫反应。TRF还能恢复来自用DNPKLH致敏并加强免疫的小鼠的T细胞缺失脾细胞培养物的二次抗半抗原IgG反应。在这里，对载体特异性的需求被完全克服。因此，数据表明TRF作为一种非抗原特异性成熟信号，参与了对颗粒性和可溶性抗原的初次和二次免疫反应。
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Mechanism of T-cell help in the immune response to soluble protein antigens II. Reconstitution of primary and secondary in vitro immune responses to dinitrophenyl-carrier conjugates by T-cell-replacing factor.T细胞辅助可溶性蛋白抗原免疫应答的机制II. 用T细胞替代因子重建对二硝基苯基-载体偶联物的初次和二次体外免疫应答
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