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T细胞辅助可溶性蛋白抗原免疫应答的机制II. 用T细胞替代因子重建对二硝基苯基-载体偶联物的初次和二次体外免疫应答

Mechanism of T-cell help in the immune response to soluble protein antigens II. Reconstitution of primary and secondary in vitro immune responses to dinitrophenyl-carrier conjugates by T-cell-replacing factor.

作者信息

Hünig T H, Schimpl A, Wecker E

出版信息

J Exp Med. 1977 May 1;145(5):1228-36. doi: 10.1084/jem.145.5.1228.

DOI:10.1084/jem.145.5.1228
PMID:323405
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2180658/
Abstract

Spleen cells of dinitrophenyl keyhole limpet hemocyanin (DNPKLH) primed and boosted mice produced a nonantigen-specific helper factor upon in vitro challenge with DNPKLH. This helper factor displays all of the biological characteristics so far described for TRF produced by allogeneic or Concanavalin A stimulation of mouse spleen cells. It restores the primary anti-SRBC response in nude spleen cultures following the same kinetics of action as T-cell-replacing factor (TRF). Conversely, TRF restores the primary in vitro immune response of nude spleen cultures to DNPKLH. TRF also restores the secondary anti-hapten IgG response of T-cell-deprived spleen cell cultures derived from DNPKLH primed and boosted mice. Here the need for carrier specificity is fully overcome. The data therefore suggest that TRF, as a nonantigen-specific maturation signal, is involved in the primary and secondary immune responses to both particulate and soluble antigens.

摘要

用二硝基苯基钥孔戚血蓝蛋白（DNPKLH）致敏并加强免疫的小鼠的脾细胞，在体外用DNPKLH攻击时产生了一种非抗原特异性辅助因子。这种辅助因子表现出了迄今所描述的由同种异体或刀豆球蛋白A刺激小鼠脾细胞产生的转移因子（TRF）的所有生物学特性。它能在裸脾培养物中恢复初次抗绵羊红细胞（SRBC）反应，其作用动力学与T细胞替代因子（TRF）相同。相反，TRF能恢复裸脾培养物对DNPKLH的体外初次免疫反应。TRF还能恢复来自用DNPKLH致敏并加强免疫的小鼠的T细胞缺失脾细胞培养物的二次抗半抗原IgG反应。在这里，对载体特异性的需求被完全克服。因此，数据表明TRF作为一种非抗原特异性成熟信号，参与了对颗粒性和可溶性抗原的初次和二次免疫反应。

相似文献

1
Mechanism of T-cell help in the immune response to soluble protein antigens II. Reconstitution of primary and secondary in vitro immune responses to dinitrophenyl-carrier conjugates by T-cell-replacing factor.T细胞辅助可溶性蛋白抗原免疫应答的机制II. 用T细胞替代因子重建对二硝基苯基-载体偶联物的初次和二次体外免疫应答
J Exp Med. 1977 May 1;145(5):1228-36. doi: 10.1084/jem.145.5.1228.
2
Mechanism of T-cell help in the immune response to soluble protein antigens. I. Evidence for in situ generation and action of T-cell-replacing factor during the anamnestic response to dinitrophenyl keyhole limpet hemocyanin in vitro.T细胞在针对可溶性蛋白抗原的免疫应答中的辅助机制。I. 体外对二硝基苯基钥孔戚血蓝蛋白进行回忆应答期间T细胞替代因子原位生成及作用的证据。
J Exp Med. 1977 May 1;145(5):1216-27. doi: 10.1084/jem.145.5.1216.
3
Regulatory functions of hapten-reactive helper and suppressor T lymphocytes. I. Detection and characterization of hapten-reactive suppressor T-cell activity in mice immunized with hapten-isologous protein conjugate.半抗原反应性辅助性和抑制性T淋巴细胞的调节功能。I. 用半抗原-同源蛋白偶联物免疫的小鼠中半抗原反应性抑制性T细胞活性的检测与特性分析。
J Exp Med. 1977 Jul 1;146(1):74-90. doi: 10.1084/jem.146.1.74.
4
Synergy between T cell-replacing factor and bacterial lipopolysaccharides (LPS) in the primary antibody response in vitro: a model for lipopolysaccharide adjuvant action.T细胞替代因子与细菌脂多糖（LPS）在体外初次抗体应答中的协同作用：脂多糖佐剂作用的一个模型
J Immunol. 1979 Apr;122(4):1421-6.
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Activation of T and B lymphocytes in vitro. IV. Regulatory influence on specific T cell functions by a thymus extract factor.T和B淋巴细胞的体外激活。IV. 胸腺提取物因子对特异性T细胞功能的调节作用。
J Immunol. 1975 Apr;114(4):1248-54.
6
Stimulation of IgG antibody response in vitro by T cell-replacing factor.T细胞替代因子对体外IgG抗体应答的刺激作用。
J Exp Med. 1973 Feb 1;137(2):547-52. doi: 10.1084/jem.137.2.547.
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Murine B-cell subpopulations responsive to T-dependent and T-independent antigens.对T细胞依赖性和T细胞非依赖性抗原产生反应的小鼠B细胞亚群。
J Exp Med. 1976 Aug 1;144(2):382-97. doi: 10.1084/jem.144.2.382.
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The allogeneic effect in inbred mice. 3. Unique antigenic structural requirements in the expression of the phenomenon on unprimed cell populations in vivo.近交系小鼠中的同种异体效应。3. 体内未致敏细胞群体中该现象表达的独特抗原结构要求。
J Exp Med. 1973 Apr 1;137(4):991-1008. doi: 10.1084/jem.137.4.991.
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Selective roles of thymus-derived lymphocytes in the antibody response. I. Differential suppressive effect of carrier-primed T cells on hapten-specific IgM and IgG antibody responses.胸腺来源淋巴细胞在抗体应答中的选择性作用。I. 载体致敏T细胞对半抗原特异性IgM和IgG抗体应答的差异抑制作用。
J Exp Med. 1974 Jul 1;140(1):239-52. doi: 10.1084/jem.140.1.239.
10
Reaginic antibody formation in the mouse. V. Adoptive antihapten IgE antibody response of dinitrophenyl-keyhole limpet hemocyanin-primed spleen cells cultured with dinitrophenyl heterologous carrier conjugates.小鼠体内反应素性抗体的形成。V. 用二硝基苯基-异源载体偶联物培养经二硝基苯基-钥孔戚血蓝蛋白致敏的脾细胞的过继抗半抗原IgE抗体反应
J Immunol. 1975 Feb;114(2 Pt 1):615-20.

引用本文的文献

1
Helper activity of T lymphocytes which have been stimulated by keyhole limpet haemocyanin in vitro.体外被钥孔戚血蓝蛋白刺激的T淋巴细胞的辅助活性。
Immunology. 1981 May;43(1):111-6.
2
Activation of murine B lymphocytes by anti-immunoglobulin is an inductive signal leading to immunoglobulin secretion.抗免疫球蛋白对鼠B淋巴细胞的激活是一种诱导信号，可导致免疫球蛋白分泌。
J Exp Med. 1980 Jul 1;152(1):138-50. doi: 10.1084/jem.152.1.138.
3
The role of H-2-linked genes in helper T cell function. VII. Expression of I region and immune response genes by B cells in bystander help assays.H-2 连锁基因在辅助性 T 细胞功能中的作用。VII. 在旁观者辅助测定中 B 细胞对 I 区基因和免疫反应基因的表达。
J Exp Med. 1980 Nov 1;152(5):1274-88. doi: 10.1084/jem.152.5.1274.
4
Receptors for T cell-replacing factor/interleukin 5. Specificity, quantitation, and its implication.T细胞替代因子/白细胞介素5的受体。特异性、定量及其意义。
J Exp Med. 1988 Sep 1;168(3):863-78. doi: 10.1084/jem.168.3.863.
5
In vitro analysis of allogeneic lymphocyte interaction. II. I-region control of the activity of a B-cell-derived H-2-restricted allogeneic effect factor and its receptor during B-cell activation.同种异体淋巴细胞相互作用的体外分析。II. B细胞活化过程中I区对B细胞衍生的H-2限制性同种异体效应因子及其受体活性的控制。
J Exp Med. 1978 Apr 1;147(4):1198-212. doi: 10.1084/jem.147.4.1198.
6
[Soluble mediators as a means of communication between lymphozytes in immune reactions (author's transl)].[可溶性介质作为免疫反应中淋巴细胞间通讯手段（作者译）]
Klin Wochenschr. 1979 Jun 15;57(12):631-40. doi: 10.1007/BF01477630.
7
Mechanism of T-cell help in the immune response to soluble protein antigens. I. Evidence for in situ generation and action of T-cell-replacing factor during the anamnestic response to dinitrophenyl keyhole limpet hemocyanin in vitro.T细胞在针对可溶性蛋白抗原的免疫应答中的辅助机制。I. 体外对二硝基苯基钥孔戚血蓝蛋白进行回忆应答期间T细胞替代因子原位生成及作用的证据。
J Exp Med. 1977 May 1;145(5):1216-27. doi: 10.1084/jem.145.5.1216.
8
Thymus dependence of the IgG response: role of T cells is restricted to non-specific rather than antigen-specific factors.IgG应答的胸腺依赖性：T细胞的作用仅限于非特异性而非抗原特异性因素。
Immunology. 1979 Jul;37(3):603-8.

本文引用的文献

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Immunization of dissociated spleen cell cultures from normal mice.对来自正常小鼠的脾细胞解离培养物进行免疫接种。
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Initiation of antibody production to sheep erythrocytes in vitro: replacement of the requirement for T-cells with a cell-free factor isolated from cultures of lymphoid cells.体外针对绵羊红细胞的抗体产生起始：用从淋巴细胞培养物中分离出的无细胞因子替代对T细胞的需求。
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The differentiation function of T cell-replacing factor in nu-nu spleen cell cultures.裸鼠脾脏细胞培养中T细胞替代因子的分化功能
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Development of primary M, G, and A anti-TNP plaque-forming cell responses in vitro.体外原发性M、G和A抗三硝基苯噬斑形成细胞反应的发展。
J Immunol. 1973 Jul;111(1):130-6.
5
Stimulation of IgG antibody response in vitro by T cell-replacing factor.T细胞替代因子对体外IgG抗体应答的刺激作用。
J Exp Med. 1973 Feb 1;137(2):547-52. doi: 10.1084/jem.137.2.547.
6
Letter: T cell-dependent mediator in the immune response.信件：免疫反应中T细胞依赖性介质。
Nature. 1973 Jun 8;243(5406):356-7. doi: 10.1038/243356a0.
7
Activation of T and B lymphocytes in vitro. II. Biological and biochemical properties of an allogeneic effect factor (AEF) active in triggering specific B lymphocytes.体外T和B淋巴细胞的激活。II. 一种在触发特异性B淋巴细胞中起作用的同种异体效应因子（AEF）的生物学和生化特性。
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8
Autoradiographic studies on the proliferation of antibody-producing cells in vitro.体外抗体产生细胞增殖的放射自显影研究。
J Exp Med. 1974 Mar 1;139(3):754-60. doi: 10.1084/jem.139.3.754.
9
The role of humoral factors in the initiation of in vitro primary immune responses. 3. Characterization of factors that replace thymus-derived cells.体液因子在体外初次免疫应答启动中的作用。3. 替代胸腺来源细胞的因子的特性
J Immunol. 1973 Nov;111(5):1301-13.
10
Replacement of T-cell function by a T-cell product.用一种T细胞产物替代T细胞功能。
Nat New Biol. 1972 May 3;237(70):15-7. doi: 10.1038/newbio237015a0.