Sundeen J T, Bloom S
Hum Pathol. 1987 Jan;18(1):96-9. doi: 10.1016/s0046-8177(87)80202-2.
A case of rupture of a sinus of Valsalva aneurysm in a middle-aged woman with an unusual assortment of associated conotruncal and other cardiac anomalies is reported. The anomalies included bicuspid aortic valve, aortic sinus aneurysm (ruptured), quadricuspid pulmonic valve, membranous coarctation of the aorta, subclavian and common carotid arteries arising directly from aorta, and atrial septal defect. Excluding the atrial septal defect, these anomalies may be explained by a single embryologic event affecting conobulbar septation and aortic arch development occurring at the level of neural crest development.
报道了一例中年女性瓦氏窦瘤破裂病例，该患者伴有一系列罕见的圆锥干及其他心脏异常。这些异常包括二叶式主动脉瓣、主动脉窦瘤（破裂）、四叶式肺动脉瓣、主动脉膜性缩窄、锁骨下动脉和颈总动脉直接发自主动脉以及房间隔缺损。排除房间隔缺损，这些异常可由影响圆锥球间隔和主动脉弓发育的单一胚胎学事件来解释，该事件发生在神经嵴发育阶段。
