Zhang Yunqi, Lv Zheng, Peng Peng, Zhao Tie
Department of Pharmacy, Guangzhou Institute of Dermatology, Guangzhou, China.
The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China.
Front Med (Lausanne). 2023 Dec 21;10:1290514. doi: 10.3389/fmed.2023.1290514. eCollection 2023.
The association between red blood cell distribution width (RDW) and psoriasis among the US adults is still unknown. We aimed to assess whether RDW is associated with psoriasis in the US adults.
We conducted a cross-sectional study consisting of 14,089 participants from National Health and Nutrition Examination Survey (NHANES) 2009-2014. Psoriasis status were assessed by self-reported questionnaire. We evaluated the association between RDW and risk of psoriasis using multivariate regression models. Subgroup and interaction analysis were performed.
The higher RDW level was associated with an increased risk of psoriasis (OR = 1.10 [95% CI, 1.01, 1.19]; = 0.025) after adjusting for confounders in female. However, there is no significant association between RDW and risk of psoriasis among male (OR = 0.99 [95% CI, 0.87, 1.15]; = 0.992). Subgroup and interaction analysis found that the strongest positive association mainly exists in female participants with BMD greater than 29.9 kg/m (OR = 1.20 [95% CI, 1.09, 1.32], Pint = 0.004).
In conclusion, we found that increased RDW levels were associated with an increased risk of psoriasis in females, which could provide clinicians with auxiliary data for the early diagnosis of psoriasis.
美国成年人中红细胞分布宽度（RDW）与银屑病之间的关联尚不清楚。我们旨在评估美国成年人中RDW是否与银屑病相关。
我们进行了一项横断面研究，研究对象为2009 - 2014年国家健康与营养检查调查（NHANES）中的14,089名参与者。通过自我报告问卷评估银屑病状况。我们使用多变量回归模型评估RDW与银屑病风险之间的关联。进行了亚组分析和交互分析。
在对女性混杂因素进行调整后，较高的RDW水平与银屑病风险增加相关（OR = 1.10 [95% CI，1.01, 1.19]；P = 0.025）。然而，男性中RDW与银屑病风险之间无显著关联（OR = 0.99 [95% CI，0.87, 1.15]；P = 0.992）。亚组分析和交互分析发现，最强的正相关主要存在于骨密度大于29.9 kg/m的女性参与者中（OR = 1.20 [95% CI，1.09, 1.32]，Pint = 0.004）。
总之，我们发现RDW水平升高与女性银屑病风险增加相关，这可为临床医生早期诊断银屑病提供辅助数据。
