Kim Das Suk, Shin Dongyun, Jee Hyunjoong, Kim Tae-Gyun, Kim Sung Hee, Kim Do Young, Kim Soo Min, Lee Min-Geol
Department of Dermatology, Severance Hospital, Cutaneous Biology Research Institute, Seoul, South Korea.
Brain Korea 21 Plus Project for Medical Science, Seoul, South Korea.
J Dermatol. 2015 Jun;42(6):567-71. doi: 10.1111/1346-8138.12865. Epub 2015 Mar 26.
Circulating inflammatory cytokines and markers are increased in patients with psoriasis. Recent studies have shown that a higher red blood cell distribution width (RDW) is associated with disease activity in various disorders. Our objective was to investigate whether RDW is increased in psoriasis patients, and to evaluate its possible association with disease severity. We conducted a retrospective study of psoriasis patients seen in a university hospital in South Korea. Information about demographics, hematological parameters and disease severity were collected. Statistical analysis was performed using Student's t-test, multivariable logistic regression, Fisher's exact test and Spearman's rank correlation coefficient analysis as appropriate. A total of 261 psoriasis patients and 102 healthy controls were included in our study. The mean RDW value was significantly increased in psoriasis patients compared with healthy control (P = 0.037). Compared with mild psoriasis patients (Psoriasis Area and Severity Index [PASI], <7), moderate to severe patients (PASI, ≥7) showed significantly higher RDW values (P = 0.044). However, RDW did not show significant correlation with PASI (P = 0.358). When patients were divided into two groups according to their RDW value (<14.6% and ≥14.6%), the mean value of PASI was not significantly different (P = 0.219). Patients with psoriasis showed increased RDW values compared with healthy controls. It was also higher in the moderate and severe disease group than the mild group. Though this is only a pilot study, it is possible that RDW value can reflect the inflammatory status of psoriasis patients.
银屑病患者循环中的炎性细胞因子和标志物会增加。最近的研究表明，较高的红细胞分布宽度（RDW）与多种疾病的疾病活动度相关。我们的目的是调查银屑病患者的RDW是否升高，并评估其与疾病严重程度的可能关联。我们对韩国一家大学医院的银屑病患者进行了一项回顾性研究。收集了有关人口统计学、血液学参数和疾病严重程度的信息。根据情况使用学生t检验、多变量逻辑回归、Fisher精确检验和Spearman等级相关系数分析进行统计分析。我们的研究共纳入了261例银屑病患者和102例健康对照。与健康对照相比，银屑病患者的平均RDW值显著升高（P = 0.037）。与轻度银屑病患者（银屑病面积和严重程度指数[PASI]，<7）相比，中度至重度患者（PASI，≥7）的RDW值显著更高（P = 0.044）。然而，RDW与PASI无显著相关性（P = 0.358）。当根据RDW值（<14.6%和≥14.6%）将患者分为两组时，PASI的平均值无显著差异（P = 0.219）。与健康对照相比，银屑病患者的RDW值升高。中度和重度疾病组的RDW值也高于轻度组。尽管这只是一项初步研究，但RDW值有可能反映银屑病患者的炎症状态。
