内在灵活性和糖涂层在 Contactin-2 同源二聚化中的相互作用。
Interplay between intrinsic flexibility and sugar coating in Contactin-2 homodimerization.
机构信息
Department of Biology and Biochemistry, University of Houston, Houston, TX 77204, USA.
出版信息
Structure. 2024 Jan 4;32(1):3-5. doi: 10.1016/j.str.2023.12.005.
PMID:38181726
Abstract
In this issue of Structure, Chataigner et al. reveal that Contactin-2's homotypic interaction, a glycosylation-dependent process, generates a broad conformational landscape. This structural plasticity, driven by conformational equilibria and sugar coating, facilitates adaptation to diverse ligands and environmental conditions, highlighting its dynamic role in neuronal function.
摘要
在本期《结构》杂志中，Chataigner 等人揭示了 Contactin-2 的同源相互作用，这是一个依赖于糖基化的过程，产生了广泛的构象景观。这种由构象平衡和糖涂层驱动的结构可塑性，促进了与各种配体和环境条件的适应，突出了其在神经元功能中的动态作用。
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