社会微生物组中的微生物传播及其与宿主健康和疾病的关系。
Microbial transmission in the social microbiome and host health and disease.
机构信息
Department of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA.
Department of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA.
出版信息
Cell. 2024 Jan 4;187(1):17-43. doi: 10.1016/j.cell.2023.12.014.
Although social interactions are known to drive pathogen transmission, the contributions of socially transmissible host-associated mutualists and commensals to host health and disease remain poorly explored. We use the concept of the social microbiome-the microbial metacommunity of a social network of hosts-to analyze the implications of social microbial transmission for host health and disease. We investigate the contributions of socially transmissible microbes to both eco-evolutionary microbiome community processes (colonization resistance, the evolution of virulence, and reactions to ecological disturbance) and microbial transmission-based processes (transmission of microbes with metabolic and immune effects, inter-specific transmission, transmission of antibiotic-resistant microbes, and transmission of viruses). We consider the implications of social microbial transmission for communicable and non-communicable diseases and evaluate the importance of a socially transmissible component underlying canonically non-communicable diseases. The social transmission of mutualists and commensals may play a significant, under-appreciated role in the social determinants of health and may act as a hidden force in social evolution.
虽然已知社交互动会促进病原体传播，但宿主相关的可传播共生生物和共生物对宿主健康和疾病的贡献仍未得到充分探索。我们使用社会微生物组的概念——宿主社交网络的微生物元群落——来分析社交微生物传播对宿主健康和疾病的影响。我们研究了可传播微生物对生态进化微生物群落过程（定植抗性、毒力进化和对生态干扰的反应）和基于微生物传播的过程（具有代谢和免疫作用的微生物传播、种间传播、抗生素抗性微生物传播和病毒传播）的贡献。我们考虑了社交微生物传播对传染性和非传染性疾病的影响，并评估了经典非传染性疾病背后具有传染性成分的重要性。共生生物和共生物的社交传播可能在健康的社会决定因素中发挥重要但未被充分认识的作用，并可能成为社会进化中的一股隐藏力量。
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