在活体系统中通过移植构建人类神经回路。

Constructing human neural circuits in living systems by transplantation.

机构信息

Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA; Stanford Brain Organogenesis Program, Wu Tsai Neurosciences Institute and Bio-X, Stanford, CA, USA.

出版信息

Cell. 2024 Jan 4;187(1):8-13. doi: 10.1016/j.cell.2023.12.008.

DOI:10.1016/j.cell.2023.12.008

PMID:38181744

Abstract

Our understanding of how the brain assembles its circuits and how this goes awry in disease remains incomplete. There has been great progress in generating human neurons from stem cells in vitro and, more recently, in constructing circuits with human cells in vivo by transplantation. Here, I highlight approaches, promises, and challenges of growing human neurons in living animals to study human development and disease.

摘要

我们对于大脑如何组装其回路以及在疾病中这一过程如何出错的理解仍然不完整。从干细胞体外生成人类神经元方面已经取得了很大的进展，而最近，通过移植在活体动物中构建具有人类细胞的回路方面也取得了进展。在这里，我重点介绍了在活体动物中培养人类神经元以研究人类发育和疾病的方法、前景和挑战。