分割受损 DNA：一把双刃剑。

Compartmentalizing damaged DNA: A double-edged sword.

机构信息

Human Technopole, Viale Rita Levi-Montalcini 1, 20157 Milano, Italy.

Human Technopole, Viale Rita Levi-Montalcini 1, 20157 Milano, Italy; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Solna, Sweden; Science for Life Laboratory, Solna, Sweden.

出版信息

Mol Cell. 2024 Jan 4;84(1):12-13. doi: 10.1016/j.molcel.2023.12.001.

DOI:10.1016/j.molcel.2023.12.001

PMID:38181754

Abstract

A recent publication in Nature by Arnould et al. describes a novel chromatin compartment, termed "damaged" or "D compartment," that facilitates the repair of DNA double-strand breaks but also increases the risk of potentially oncogenic translocation formation.

摘要

最近，Arnould 等人在《自然》杂志上发表的一篇文章描述了一种新型染色质隔室，称为“损伤”或“D 隔室”，它有助于修复 DNA 双链断裂，但也增加了潜在致癌易位形成的风险。