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Sperm epigenetic mechanisms in autism spectrum disorders. The valproate case illustrates an enduring and systemic failure.

作者信息

Martin Marine, Braillon Alain

机构信息

Association to Help Parents of Children Suffering from Anti-Convulsant Syndrome (APESAC), 8 rue Ramon Saguardia, 66450, Pollestres, France.

, 80000, Amiens, France.

出版信息

Mol Psychiatry. 2024 Apr;29(4):1163-1164. doi: 10.1038/s41380-023-02401-8. Epub 2024 Jan 5.

DOI:10.1038/s41380-023-02401-8
PMID:38182807
Abstract
摘要

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Sperm epigenetic mechanisms in autism spectrum disorders. The valproate case illustrates an enduring and systemic failure.自闭症谱系障碍中的精子表观遗传机制。丙戊酸盐案例说明了一种持续且系统性的失败。
Mol Psychiatry. 2024 Apr;29(4):1163-1164. doi: 10.1038/s41380-023-02401-8. Epub 2024 Jan 5.
2
[Epigenetics' implication in autism spectrum disorders: A review].[表观遗传学在自闭症谱系障碍中的影响：综述]
Encephale. 2017 Aug;43(4):374-381. doi: 10.1016/j.encep.2016.07.007. Epub 2016 Sep 28.
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Role of environmental factors and epigenetics in autism spectrum disorders.环境因素与表观遗传学在自闭症谱系障碍中的作用。
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Risk of Neurodevelopmental Disease by Paternal Aging: A Possible Influence of Epigenetic Alteration in Sperm.父系衰老导致神经发育性疾病的风险：精子中表观遗传改变的可能影响。
Adv Exp Med Biol. 2018;1012:75-81. doi: 10.1007/978-981-10-5526-3_8.
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Transgenerational epigenetic information through the sperm: Sperm cells not just merely supply half of the genome for new life; they also seem to transmit additional information via epigenetic modifications.通过精子传递跨代表观遗传信息：精子不仅为新生命提供了一半的基因组；它们似乎还通过表观遗传修饰传递额外的信息。
EMBO Rep. 2021 Aug 4;22(8):e53539. doi: 10.15252/embr.202153539. Epub 2021 Jul 20.
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Epigenetic mechanisms: A possible link between autism spectrum disorders and fetal alcohol spectrum disorders.表观遗传机制：自闭症谱系障碍与胎儿酒精谱系障碍之间的一种可能联系。
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Roles of Epigenetics and Glial Cells in Drug-Induced Autism Spectrum Disorder.表观遗传学和神经胶质细胞在药物诱发的自闭症谱系障碍中的作用。
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Paternal sperm DNA methylation associated with early signs of autism risk in an autism-enriched cohort.在一个自闭症高发队列中，父系精子DNA甲基化与自闭症风险的早期迹象相关。
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Sexually Dimorphic Epigenetic Regulation of Brain-Derived Neurotrophic Factor in Fetal Brain in the Valproic Acid Model of Autism Spectrum Disorder.自闭症谱系障碍丙戊酸模型中胎儿大脑源性神经营养因子的性别二态性表观遗传调控
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Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism.产前丙戊酸盐暴露与自闭症谱系障碍和儿童自闭症的风险。
JAMA. 2013 Apr 24;309(16):1696-703. doi: 10.1001/jama.2013.2270.

本文引用的文献

1
Testicular histone hyperacetylation in mice by valproic acid administration affects the next generation by changes in sperm DNA methylation.丙戊酸给药导致的小鼠睾丸组蛋白乙酰化过度会通过精子 DNA 甲基化的改变影响下一代。
PLoS One. 2023 Mar 9;18(3):e0282898. doi: 10.1371/journal.pone.0282898. eCollection 2023.
2
Inheritance of paternal lifestyles and exposures through sperm DNA methylation.通过精子 DNA 甲基化遗传父系生活方式和暴露。
Nat Rev Urol. 2023 Jun;20(6):356-370. doi: 10.1038/s41585-022-00708-9. Epub 2023 Jan 18.
3
Role of epigenetic transgenerational inheritance in generational toxicology.
表观遗传跨代遗传在代际毒理学中的作用。
Environ Epigenet. 2022 Feb 16;8(1):dvac001. doi: 10.1093/eep/dvac001. eCollection 2022.
4
Contributions of epigenetic inheritance to the predisposition of major psychiatric disorders: Theoretical framework, evidence, and implications.表观遗传遗传对主要精神障碍易感性的贡献：理论框架、证据和意义。
Neurosci Biobehav Rev. 2022 Apr;135:104579. doi: 10.1016/j.neubiorev.2022.104579. Epub 2022 Feb 12.
5
Transgenerational adverse effects of valproate? A patient report from 90 affected families.丙戊酸盐的跨代不良反应？来自90个受影响家庭的病例报告。
Birth Defects Res. 2022 Jan 1;114(1):13-16. doi: 10.1002/bdr2.1967. Epub 2021 Dec 5.
6
The transgenerational inheritance of autism-like phenotypes in mice exposed to valproic acid during pregnancy.孕期暴露于丙戊酸的小鼠中自闭症样表型的跨代遗传。
Sci Rep. 2016 Nov 7;6:36250. doi: 10.1038/srep36250.
7
Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen.组蛋白脱乙酰酶是丙戊酸的直接靶点，丙戊酸是一种有效的抗惊厥药、情绪稳定剂和致畸剂。
J Biol Chem. 2001 Sep 28;276(39):36734-41. doi: 10.1074/jbc.M101287200. Epub 2001 Jul 25.
8
Psychiatric epigenetics: a new focus for the new century.
Mol Psychiatry. 2000 Jul;5(4):342-6. doi: 10.1038/sj.mp.4000750.
9
Prenatal exposure of rats to valproic acid reproduces the cerebellar anomalies associated with autism.
Neurotoxicol Teratol. 2000 May-Jun;22(3):319-24. doi: 10.1016/s0892-0362(99)00083-5.
10
Fetal valproate syndrome: clinical and neuro-developmental features in two sibling pairs.胎儿丙戊酸盐综合征：两对同胞兄妹的临床及神经发育特征
Dev Med Child Neurol. 1994 Apr;36(4):361-9. doi: 10.1111/j.1469-8749.1994.tb11858.x.