Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Anzhen Road, Beijing, 100029, China.
Cardiovasc Diabetol. 2024 Jan 6;23(1):16. doi: 10.1186/s12933-023-02114-w.
Findings from earlier research have established that insulin resistance (IR) is implicated in atherosclerosis progression, representing a noteworthy risk factor for cardiovascular disease (CVD). Recently, the triglyceride glucose-body mass index (TyG-BMI) has been introduced as a straightforward and robust alternative indicator for early detection of IR. Nevertheless, there is a scarcity of studies that have examined the capability of TyG-BMI for predicting incident CVD. Consequently, the core objective of this study was to determine whether the cumulative average TyG-BMI correlated with CVD incidence.
All data was sourced from the China Health and Retirement Longitudinal Study (CHARLS). The exposure was the cumulative average TyG-BMI, determined by the average of TyG-BMI values for the baseline and follow-up investigations (Wave 1 in 2011, Wave 3 in 2015, respectively). The calculation of TyG-BMI involved a combination of triglyceride, fasting blood glucose, and body mass index. The primary outcome was incident CVD. Logistic regression analyses as well as restricted cubic spline (RCS) regression analyses were performed for examining the association between the cumulative average TyG-BMI and CVD incidence.
In all, 5,418 participants were enrolled in our analysis, with 2,904 (53.6%) being female, and a mean (standard deviation, SD) age of 59.6 (8.8) years. The mean (SD) cumulative average TyG-BMI among all participants was 204.9 (35.7). Totally, during a 4-year follow-up, 543 (10.0%) participants developed CVD. The fully adjusted logistic regression analysis revealed a significant association between the cumulative average TyG-BMI and incident CVD [odds ratio (OR), 95% confidence interval (CI): 1.168, 1.040-1.310, per 1 SD increase]. The RCS regression analysis displayed a positive, linear association of the cumulative average TyG-BMI with CVD incidence (P for overall = 0.038, P for nonlinear = 0.436).
Our study revealed a noteworthy correlation between the cumulative average TyG-BMI and incident CVD among the middle-aged and older population. The cumulative average TyG-BMI emerges as a valuable tool that may enhance the primary prevention and treatment of CVD.
早期研究发现，胰岛素抵抗（IR）与动脉粥样硬化进展有关，是心血管疾病（CVD）的一个重要危险因素。最近，甘油三酯-葡萄糖-体重指数（TyG-BMI）已被作为一种简单而有效的替代指标用于早期检测 IR。然而，目前关于 TyG-BMI 预测 CVD 事件的能力的研究还很少。因此，本研究的核心目标是确定累积平均 TyG-BMI 是否与 CVD 发生率相关。
所有数据均来自中国健康与养老追踪调查（CHARLS）。暴露因素为累积平均 TyG-BMI，通过基线和随访调查（分别为 2011 年的第 1 波和 2015 年的第 3 波）的 TyG-BMI 值的平均值确定。TyG-BMI 的计算涉及甘油三酯、空腹血糖和体重指数。主要结局是 CVD 事件。Logistic 回归分析和限制性立方样条（RCS）回归分析用于研究累积平均 TyG-BMI 与 CVD 发生率之间的关系。
共有 5418 名参与者纳入本分析，其中 2904 名（53.6%）为女性，平均（标准差，SD）年龄为 59.6（8.8）岁。所有参与者的平均（SD）累积平均 TyG-BMI 为 204.9（35.7）。在 4 年的随访期间，共有 543 名（10.0%）参与者发生 CVD。完全调整的 logistic 回归分析显示，累积平均 TyG-BMI 与 CVD 事件之间存在显著关联[比值比（OR），95%置信区间（CI）：1.168，1.040-1.310，每增加 1 个 SD]。RCS 回归分析显示，累积平均 TyG-BMI 与 CVD 发生率呈正线性关联（总体 P=0.038，非线性 P=0.436）。
本研究表明，中年和老年人的累积平均 TyG-BMI 与 CVD 事件之间存在显著相关性。累积平均 TyG-BMI 是一种有价值的工具，可用于增强 CVD 的一级预防和治疗。
