Eisen E J
J Anim Sci. 1987 Jan;64(1):133-47. doi: 10.2527/jas1987.641133x.
Correlated responses to selection for rapid 3 to 6-wk postweaning gain in male mice were estimated for five fat depots weighed at specific degrees of maturity in body weight (37.5, 50.0, 62.5, 75, 87.5 and 100%). Fat pads measured were from regions of the subcutaneous hindlimb, subcutaneous forelimb, epididymides, mesentery and kidneys. At the same degree of maturity, selected mice (M16) were older (P less than .01) than controls (ICR). M16 had heavier (P less than .01) fat depots than ICR for all sites at each degree of maturity. From 62.5 to 100% maturity, M16 was larger than ICR in fat depot weight as a percentage of body weight at all sites. Mesenteric fat made up the largest percentage of total fat in both lines and perirenal fat the smallest percentage. Development of degree of maturity in each fat depot relative to degree of maturity in body weight was studied using the constrained quadratic and standardized allometric models. Both models showed similar trends, but the latter identified more significant line differences. The standardized allometric analysis indicated that total fat and all individual fat depots except mesenteric fat matured at a slower rate (P less than .01) in M16 than in ICR. Bivariate allometric analyses of ln fat depot weight on ln body weight showed that M16 exceeded (P less than .01) ICR in relative growth of all fat depots except mesenteric fat; at lower body weights, ICR had larger fat depots than M16, but the reverse was true at higher body weights.(ABSTRACT TRUNCATED AT 250 WORDS)
对雄性小鼠断奶后3至6周快速增重选择的相关反应进行了评估，测量了五个脂肪库在特定体重成熟度（37.5%、50.0%、62.5%、75%、87.5%和100%）时的重量。测量的脂肪垫来自后肢皮下、前肢皮下、附睾、肠系膜和肾脏区域。在相同成熟度下，选择的小鼠（M16）比对照组（ICR）年龄更大（P小于0.01）。在每个成熟度下，M16所有部位的脂肪库都比ICR更重（P小于0.01）。从62.5%到100%成熟度，M16所有部位脂肪库重量占体重的百分比均大于ICR。肠系膜脂肪在两品系中占总脂肪的比例最大，肾周脂肪占比最小。使用约束二次模型和标准化异速生长模型研究了每个脂肪库成熟度相对于体重成熟度的发育情况。两个模型显示出相似的趋势，但后者识别出更显著的品系差异。标准化异速生长分析表明，除肠系膜脂肪外，M16的总脂肪和所有单个脂肪库成熟速度均比ICR慢（P小于0.01）。对脂肪库重量的自然对数与体重的自然对数进行双变量异速生长分析表明，除肠系膜脂肪外，M16所有脂肪库的相对生长均超过ICR（P小于0.01）；在较低体重时，ICR的脂肪库比M16大，但在较高体重时则相反。（摘要截短于250字）
