Eisen E J, Leatherwood J M
J Nutr. 1978 Oct;108(10):1652-62. doi: 10.1093/jn/108.10.1652.
Male mice from a line selected for rapid postweaning growth (M16) and an unselected control (ICR) were reared from birth to 3 weeks either in litters of eight (N8) or 14 (N14). Body weight gain and feed intake of M16 mice were greater than ICR. These high rates of gain and feed intake also were extended to an older age in M16 (10 weeks) than in ICR (6 weeks). The M16 line exceeded the ICR line and N8 mice exceeded N14 for fat, lean, ash, and live body weights at 4, 6, 10, 16, and 30 weeks of age. Fat percentage was greater in N8 than N14 for both ICR and M16. The adipose cellularity of the epididymal fat pads of M16 indicated a hypertrophic-hyperplastic form of obesity at 10, 16, and 30 weeks. Within each line, the N14 mice had fewer and slightly smaller fat cells than N8. However, M16-N14 mice still had considerably more and larger fat cells than ICR-N8. Restriction of energy intake from birth to 3 weeks reduced subsequent feed intake and degree of obesity. After 4 weeks, the genetic effect exerted a greater influence on the development of obesity than the preweaning nutritional regimen.
从一个经过选择用于断奶后快速生长的品系（M16）中选取的雄性小鼠和一个未经过选择的对照品系（ICR），从出生到3周龄期间，分别饲养在每组8只（N8）或14只（N14）的同窝仔鼠中。M16小鼠的体重增加和采食量均高于ICR小鼠。M16小鼠（10周龄）比ICR小鼠（6周龄）的这种高生长率和采食量持续的年龄更大。在4、6、10、16和30周龄时，M16品系在脂肪、瘦肉、灰分和活体体重方面超过ICR品系，N8小鼠超过N14小鼠。对于ICR和M16品系，N8组的脂肪百分比均高于N14组。M16品系附睾脂肪垫的脂肪细胞构成在10、16和30周龄时呈现出肥大 - 增生型肥胖。在每个品系内，N14小鼠的脂肪细胞数量比N8小鼠少且略小。然而，M16 - N14小鼠的脂肪细胞数量和大小仍比ICR - N8小鼠多得多且大得多。从出生到3周龄限制能量摄入可降低随后的采食量和肥胖程度。4周龄后，遗传效应比断奶前的营养方案对肥胖的发展产生更大影响。
