Li Fanmei, Meng Zhilin, Hua Jing, Li Wei, Lou Hongxiang, Liu Lei
Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Jinan 250012, P. R. China.
Org Biomol Chem. 2015 May 28;13(20):5710-5. doi: 10.1039/c5ob00277j. Epub 2015 Apr 21.
An effective indium-catalyzed oxidative cross-dehydrogenative coupling of electronically varied chromenes with 1,3-dicarbonyl compounds and aryl rings has been established. Both the C-H alkylation and arylation proceed smoothly at room temperature to afford diverse α-substituted chromene compounds in up to 91% yields. Besides these two types of C-H components, simple ketones like cyclohexanones also prove to be well tolerated.
已建立了一种有效的铟催化的电子性质各异的色烯与1,3 - 二羰基化合物及芳环的氧化交叉脱氢偶联反应。C-H烷基化和芳基化反应在室温下均顺利进行，可得到产率高达91%的多种α-取代色烯化合物。除了这两类C-H组分外，像环己酮这样的简单酮类也被证明具有良好的耐受性。
