Oduoye Malik Olatunde, Haider Muhammad Usman, Marsool Mohammed Dheyaa Marsool, Kareem Mayowa Odunayo, Adedayo Adenike Ebunoluwa, Abdulkarim Abdulkarim Surajo, Adegoke Abdullahi Adeyemi, Kaushik Ikshwaki, Irfan Hamza, Yusuf Hassan Abdullahi, Shah Hussain Haider, Karim Karim Arif
Department of Medical Education/Research Medical Research Circle (MedReC) Bukavu Congo.
Department of Internal Medicine, Mayo Hospital Lahore King Edward Medical University Lahore Lahore Pakistan.
Health Sci Rep. 2024 Jan 4;7(1):e1797. doi: 10.1002/hsr2.1797. eCollection 2024 Jan.
Mass malaria vaccination, rather than vaccinating only children below age 5, has been proven to have the potential to reduce morbidity and mortality among those vaccinated, both young and old. Addressing vaccine scepticism and misinformation is crucial in African nations to build public trust in malaria prevention. Therefore, including a wider range of demographics in vaccine trials is necessary for equitable representation and achieving herd immunity against malaria.
This present article aims to identify some of the obstacles that impede malaria vaccination usage and acceptability in African Nations in combating malaria in the region as it continues to pose a significant global public health problem.
A literature search was done on the Malaria vaccine between 2000 and 2023. Past and present articles/studies on this topic were consulted on PubMed, Google Scholar, Scopus and Web of Science using the following keywords; "Malaria," "Vaccines," "African Nations," "Obstacles, Strategies," and "Public Health."
The recently approved RTS, S/AS01, and R21/Matrix-M™ Malaria vaccines have the potential to prevent numerous deaths and cases of Malaria in Africa. These vaccines Malaria vaccines are cost-effective in African areas with moderate to high plasmodium falciparum and can be delivered through routine immunization.
To combat malaria effectively in African Nations, African leaders need to set up a comprehensive approach that involves; prevention, healthcare access, implementation research strategies towards adoption and acceptance of malaria vaccines in Africa as well as community engagement with the religious leaders, the market women, community heads, schools, as well as students' union towards the willingness and acceptability of the malaria vaccines among the African populations.
大规模疟疾疫苗接种，而非仅对5岁以下儿童进行接种，已被证明有潜力降低接种者（无论老少）的发病率和死亡率。在非洲国家，解决疫苗怀疑论和错误信息对于建立公众对疟疾预防的信任至关重要。因此，在疫苗试验中纳入更广泛的人口统计数据对于公平代表性以及实现针对疟疾的群体免疫是必要的。
本文旨在识别一些阻碍非洲国家疟疾疫苗接种使用和可接受性的障碍，因为疟疾在该地区仍然是一个重大的全球公共卫生问题，而疫苗接种是抗击疟疾的手段之一。
对2000年至2023年期间的疟疾疫苗进行了文献检索。使用以下关键词在PubMed、谷歌学术、Scopus和科学网查阅了关于该主题的过去和现在的文章/研究；“疟疾”、“疫苗”、“非洲国家”、“障碍、策略”和“公共卫生”。
最近批准的RTS,S/AS01和R21/Matrix-M™疟疾疫苗有潜力预防非洲大量的疟疾死亡和病例。这些疟疾疫苗在恶性疟原虫感染率为中度至高的非洲地区具有成本效益，并且可以通过常规免疫接种来提供。
为了在非洲国家有效抗击疟疾，非洲领导人需要制定一种全面的方法，该方法包括；预防、医疗保健获取、针对非洲采用和接受疟疾疫苗的实施研究策略，以及与宗教领袖、市场女性、社区负责人、学校以及学生会进行社区互动，以提高非洲人群对疟疾疫苗的意愿和可接受性。
