Bjørke-Monsen Anne-Lise, Ueland Per Magne
Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, 5021 Bergen, Norway.
Department of Clinical Science, University of Bergen, Bergen, Norway.
Food Nutr Res. 2023 Dec 19;67. doi: 10.29219/fnr.v67.10259. eCollection 2023.
Pyridoxal 5´-phosphate (PLP) is the main form of vitamin B in animal tissue and functions as a coenzyme for more than 160 different enzymatic reactions in the metabolism of amino acids, carbohydrates, lipids, and neurotransmitters. Estimated dietary intake of vitamin B and plasma PLP values differ a lot between studies, something which may be due to variable use of supplements, variations in dietary assessment and analytical methods. These factors make it difficult to achieve precise data for setting a correct recommended intake of vitamin B. In addition, a plasma PLP concentration of 30 nmol/L is considered to be sufficient and the current recommendations for vitamin B intake is based on this concept. However, the metabolic marker for vitamin B status, HK ratio (HKr), starts to increase already when plasma PLP falls below 100 nmol/L and increases more steeply below 50 nmol/L, indicating biochemical deficiency. Consequently, a plasma PLP concentration of 30 nmol/L, may be too low as a marker for an adequate vitamin B status.
磷酸吡哆醛（PLP）是维生素B在动物组织中的主要形式，在氨基酸、碳水化合物、脂质和神经递质的代谢过程中，作为160多种不同酶促反应的辅酶发挥作用。不同研究中，维生素B的估计膳食摄入量和血浆PLP值差异很大，这可能是由于补充剂的使用方式不同、膳食评估和分析方法存在差异。这些因素使得难以获得精确数据来确定正确的维生素B推荐摄入量。此外，血浆PLP浓度为30 nmol/L被认为是足够的，目前关于维生素B摄入量的建议就是基于这一概念。然而，维生素B状态的代谢标志物HK比率（HKr）在血浆PLP降至100 nmol/L以下时就开始升高，在低于50 nmol/L时升高得更陡峭，表明存在生化缺乏。因此，血浆PLP浓度为30 nmol/L作为充足维生素B状态的标志物可能太低了。
