Truong Van-Long, Jeong Woo-Sik
Food and Bio-Industry Research Institute, School of Food Science & Biotechnology, College of Agriculture and Life Sciences, Kyungpook National University, Daegu 41566, Korea.
Prev Nutr Food Sci. 2023 Dec 31;28(4):411-417. doi: 10.3746/pnf.2023.28.4.411.
Rosehip ( L.) seeds, a by-product of the food processing industry, contain various bioactive compounds that have potential cosmetic and pharmacological applications. Rosehip seed oil (RHSO) has been shown to exert therapeutic effects in skin disorders, but its role in promoting hair growth remains unknown. In this study, we aimed to elucidate the hair growth-promoting activity of RHSO and the related mechanisms of action. The depleted dorsal skin of telogenic C57BL/6 mice was topically treated with RHSO for 21 days, and the extent of hair regrowth was assessed. The results indicated that RHSO stimulated hair growth by inducing the early transition of hair follicles from telogen to anagen phase. Histological analysis revealed significant increases in hair follicle density, hair bulb size, and skin thickness. RHSO treatment also upregulated the expression of hair growth-associated genes, including β-catenin, phospho-glycogen synthase kinase-3 beta, Sonic hedgehog, smoothened, cyclin D1, cyclin E, and insulin like growth factor 1. These findings suggest that RHSO stimulates hair growth and may show promise as a preventive and/or therapeutic agent for hair loss.
玫瑰果（蔷薇科）种子是食品加工业的一种副产品，含有多种具有潜在化妆品和药理学应用价值的生物活性化合物。玫瑰果籽油（RHSO）已被证明在皮肤疾病中具有治疗作用，但其在促进头发生长方面的作用尚不清楚。在本研究中，我们旨在阐明RHSO促进头发生长的活性及其相关作用机制。用RHSO对处于休止期的C57BL/6小鼠背部脱毛皮肤进行局部治疗21天，并评估毛发生长的程度。结果表明，RHSO通过诱导毛囊从休止期到生长期的早期转变来刺激头发生长。组织学分析显示毛囊密度、毛球大小和皮肤厚度显著增加。RHSO处理还上调了与头发生长相关基因的表达，包括β-连环蛋白、磷酸化糖原合酶激酶-3β、音猬因子、平滑受体、细胞周期蛋白D1、细胞周期蛋白E和胰岛素样生长因子1。这些发现表明，RHSO能刺激头发生长，可能有望成为一种预防和/或治疗脱发的药物。
