Dewedar Ola Abdel Moneim, Habba Doaa Adel, Zaki Heba Abdelfatah, Elamin Enas Ahmed, Ibrahim Amal Ali, Ahmed Omneya Emam
Oral Health Prev Dent. 2025 Aug 5;23:419-425. doi: 10.3290/j.ohpd.c_2158.
This study aimed to determine the impact of rose hip oil emulsion (ROE) on the healing of oral ulcers. The study first utilised the MTT kit to examine the effect of 20 mg/mL ROE on human gingival fibroblast (HGF) proliferation at the cellular level and its effect in treating oral mucosal ulcers at the experimental level.
Sixty-six adult male rats with a chemically induced ulcer in the buccal mucosa. The animals were distributed randomly into two groups: a control group that had not received any treatment and a test group that was treated with topical ROE 3 times per day for 10 days. The samples were obtained on day 3, day 7, and day 10, and then the tissue staining was done using hematoxylin and eosin (H&E) and histomorphometric analysis.
The findings of this study demonstrated from cellular investigations that 20 mg/mL ROE can efficiently stimulate HGF proliferation at 24, 48, and 72 h. The animal study results revealed that ROE could substantially boost the healing of the induced ulcer model by lowering the inflammatory cells and extensively promoting collagen formation within the ulcer site on days 3 and 7.
The topical application of 20 mg/mL ROE possesses anti-inflammatory properties, increasing the epithelium thickness and promoting collagen production and remodelling. Therefore, the rosehip oil emulsion can be considered an effective pro-healing agent that accelerates the healing of oral ulcers.
本研究旨在确定玫瑰果油乳剂（ROE）对口腔溃疡愈合的影响。该研究首先利用MTT试剂盒在细胞水平上检测20mg/mL ROE对人牙龈成纤维细胞（HGF）增殖的影响，并在实验水平上检测其对口腔黏膜溃疡的治疗效果。
66只成年雄性大鼠，其颊黏膜有化学诱导溃疡。将动物随机分为两组：未接受任何治疗的对照组和每天局部应用ROE 3次、持续10天的试验组。在第3天、第7天和第10天获取样本，然后使用苏木精和伊红（H&E）进行组织染色并进行组织形态计量分析。
本研究的细胞研究结果表明，20mg/mL ROE在24、48和72小时能有效刺激HGF增殖。动物研究结果显示，ROE可通过减少炎症细胞并在第3天和第7天广泛促进溃疡部位的胶原蛋白形成，从而显著促进诱导溃疡模型的愈合。
局部应用20mg/mL ROE具有抗炎特性，可增加上皮厚度，促进胶原蛋白生成和重塑。因此，玫瑰果油乳剂可被视为一种有效的促进愈合剂，能加速口腔溃疡的愈合。
