McGill University, Montreal, Quebec, Canada.
Université de Montreal, Montreal, Quebec, Canada.
J Cosmet Dermatol. 2024 Jan;23(1):62-67. doi: 10.1111/jocd.15971. Epub 2023 Aug 21.
Each year, over 100 million patients are afflicted with new scars from medical procedures worldwide. Natural compounds have shown promise in the treatment of scars and skin disorders. Rosehip oil (RO), produced from the pressed fruit of the rosehip (Rosa canina L.) plant, is used in the pharmaceutical, cosmetic, and food industries. The use of this plant in the treatment of scars has yet to be reviewed.
This review aims to analyze the current findings on the use of RO in the treatment of postsurgical scars.
This literature search considered published journal articles (clinical trials or literature reviews). Studies were identified by searching electronic databases (PubMed and MEDLINE) and reference lists of respective articles. Additional articles were identified through Google Scholar. Only articles available in English were included in this review.
There is a scarcity of high-quality studies assessing the therapeutic potential of RO. From the two human clinical trials using RO, there is some evidence to suggest its potential as an active ingredient in topical formulations for the treatment of wounds. Topical treatments containing RO extract may reduce the size and erythema of postsurgical scars through the polarization of macrophages and the inhibition of inflammatory cytokines.
Some evidence suggests that RO may improve postsurgical scars. At present, there is insufficient evidence to recommend the use of RO for the treatment of wounds. Further investigation is required to establish its therapeutic effects on human skin and its potential use as an ingredient in topical formulations.
每年，全世界有超过 1 亿名患者因医疗程序而新生成疤痕。天然化合物在治疗疤痕和皮肤疾病方面显示出了一定的前景。玫瑰果油（RO）是从玫瑰果（Rosa canina L.）植物的压榨果实中提取的，被应用于制药、化妆品和食品行业。该植物在治疗疤痕方面的应用尚未被综述过。
本综述旨在分析 RO 治疗手术后疤痕的现有研究结果。
这项文献检索考虑了已发表的期刊文章（临床试验或文献综述）。通过搜索电子数据库（PubMed 和 MEDLINE）和各自文章的参考文献列表来确定研究。通过 Google Scholar 还确定了其他文章。本综述仅纳入了英语的文章。
评估 RO 治疗潜力的高质量研究稀缺。从两项使用 RO 的人体临床试验来看，有一些证据表明它可能是治疗伤口的局部制剂中的一种有效成分。含有 RO 提取物的局部治疗可能通过巨噬细胞的极化和抑制炎症细胞因子来减少手术后疤痕的大小和红斑。
一些证据表明 RO 可能改善手术后疤痕。目前，尚无足够的证据推荐 RO 用于治疗伤口。需要进一步的研究来确定其对人类皮肤的治疗效果及其作为局部制剂成分的潜在用途。
