Veldhuis J D, Evans W S, Rogol A D, Thorner M O, Stumpf P
J Clin Invest. 1987 Mar;79(3):769-76. doi: 10.1172/JCI112883.
We assessed the time-dependent impact of estradiol on properties of the luteinizing hormone (LH) pulse signal in 12 hypoestrogenemic postmenopausal volunteers studied basally and after 1, 5, 10, and 30 d of estradiol delivery via an intravaginal Silastic ring. Computerized analysis of the plasma LH time series revealed a significant decrease in LH pulse frequency within 24 h of estrogen treatment, followed by a secondary increase (days 5 and 10), and then a sustained decline (day 30) in LH pulsatility. Estradiol also significantly suppressed incremental and maximal (but not fractional) LH pulse amplitudes in a biphasic manner. In contrast, LH peak duration was invariant until day 30 of estradiol replacement. These observations indicate that the well recognized biphasic actions of estradiol on mean serum LH concentrations can be modeled in relation to specific and time-dependent alterations in LH pulse frequency and amplitude.
我们评估了雌二醇对12名雌激素水平低下的绝经后志愿者促黄体生成素（LH）脉冲信号特性的时间依赖性影响，这些志愿者在基线状态以及通过阴道硅橡胶环给予雌二醇1、5、10和30天后接受研究。对血浆LH时间序列的计算机分析显示，雌激素治疗后24小时内LH脉冲频率显著降低，随后出现二次升高（第5天和第10天），然后LH脉冲性持续下降（第30天）。雌二醇还以双相方式显著抑制LH脉冲的增量和最大（但不是分数）幅度。相比之下，在雌二醇替代治疗至第30天之前，LH峰值持续时间不变。这些观察结果表明，雌二醇对平均血清LH浓度的公认双相作用可以根据LH脉冲频率和幅度的特定及时间依赖性变化进行建模。
