Mukawa K, Nakamura T, Nakano G, Nagamachi Y
J Clin Pathol. 1987 Jan;40(1):13-8. doi: 10.1136/jcp.40.1.13.
Minute lesions of intestinal metaplasia composed of a few metaplastic tubules were observed in the gastric mucosa during routine histological examination of gastrectomy specimens. The histological findings indicated that these lesions might be an initial stage of more advanced intestinal metaplasia. Accordingly, more than 18,000 serial sections in 10 stomachs with chronic ulcers were examined to clarify the histopathogenesis of the intestinal metaplasia. It was concluded from the three dimensional reconstruction of minute intestinal metaplasia lesions that these lesions originated during the regenerative process of healing of gastric erosions. The lesions were roughly globoid with a depression on the surface. It is thought that with continuous formation and healing of gastric erosions, more extensive intestinal metaplasia lesions would be formed by an increase in size and confluence of these focal minute intestinal metaplasia lesions.
在胃切除术标本的常规组织学检查中，在胃黏膜中观察到由少数化生小管组成的微小肠化生病变。组织学结果表明，这些病变可能是更高级别肠化生的初始阶段。因此，对10例患有慢性溃疡的胃的18000多张连续切片进行了检查，以阐明肠化生的组织发病机制。从微小肠化生病变的三维重建得出结论，这些病变起源于胃糜烂愈合的再生过程中。病变大致呈球状，表面有凹陷。据认为，随着胃糜烂的不断形成和愈合，这些局灶性微小肠化生病变的大小增加和融合会形成更广泛的肠化生病变。
