Watanabe H
Gastroenterology. 1978 Nov;75(5):796-9.
The gastric region of 5-week-old female Wistar rats was irradiated daily with 500 rad of X-ray up to a total of six times. Goblet cells and marker enzymes of the small intestine, such as lactase, trehalase, and maltase, appeared in the pyloric region of the glandular stomach of the rats from the 1st week after final irradiation. Intestinal type crypt without Paneth cells was observed from the 8th week. Sucrase activity appeared from the 26th week. Intestinal metaplasia with Paneth cells appeared from the 71st week. The number of goblet cells, intestinal type crypts, and Paneth cells increased with age. Gastric adenocarcinoma did not develop after irradiation.
对5周龄雌性Wistar大鼠的胃区每天进行500拉德的X射线照射，共照射6次。从末次照射后的第1周起，大鼠腺胃幽门区出现了杯状细胞以及小肠的标记酶，如乳糖酶、海藻糖酶和麦芽糖酶。从第8周开始观察到无潘氏细胞的肠型隐窝。蔗糖酶活性从第26周开始出现。有潘氏细胞的肠化生从第71周开始出现。杯状细胞、肠型隐窝和潘氏细胞的数量随年龄增加。照射后未发生胃腺癌。
