Rubio C A, Jessurun J
Department of Pathology, Hospital General, Universidad Autonoma, Mexico, DF.
Jpn J Cancer Res. 1992 May;83(5):491-4. doi: 10.1111/j.1349-7006.1992.tb01954.x.
A systematic analysis of the cellular and structural components of intestinal metaplasia (IM) was carried out in 691 consecutive endoscopic gastric biopsies from Mexicans patients. Two-thirds of the patients (461 or 66.7%) had chronic gastritis, 27.6% (or 191 patients) had gastric ulcers and 5.6% (39 patients) gastric carcinomas. IM was found in 17.4% of the gastric biopsies. While IM was present in 27.7% of patients with gastric peptic ulcer, patients with gastric malignancy had only 18.7%, and the lowest rate (13.4%) was found in 461 biopsies from patients with chronic gastritis. IM was influenced by the age but not by the sex of the patients. Only one of 120 biopsies with IM (0.8%) had incomplete IM (a lesion claimed to be a precursor of gastric carcinoma). In a previous study it was found that 32.3% of 359 Swedish patients and 59.2% of 625 Japanese patients with chronic gastritis had IM, the proportion of incomplete IM being 23.3% and 25.1%, respectively. The low frequency of IM among Mexicans (a population with a low incidence of gastric carcinoma), contrasts with the moderate frequency of IM among Swedes (who have a moderate gastric cancer incidence) and with the high frequency of IM among Japanese (with a high incidence of gastric carcinoma). These findings recorded in disparate geographical regions strongly support the view that IM is a lesion evoked by environmental factors and associated with gastric carcinogenesis.
对691例连续的墨西哥患者的内镜胃活检组织进行了肠化生（IM）细胞和结构成分的系统分析。三分之二的患者（461例，占66.7%）患有慢性胃炎，27.6%（即191例患者）患有胃溃疡，5.6%（39例患者）患有胃癌。在17.4%的胃活检组织中发现了IM。虽然IM在27.7%的胃溃疡患者中存在，但胃癌患者中仅为18.7%，而在461例慢性胃炎患者的活检组织中发现率最低（13.4%）。IM受患者年龄影响，但不受性别影响。120例有IM的活检组织中仅有1例（0.8%）为不完全IM（一种被认为是胃癌前体的病变）。在先前的一项研究中发现，359例瑞典慢性胃炎患者中有32.3%、625例日本慢性胃炎患者中有59.2%存在IM，不完全IM的比例分别为23.3%和25.1%。墨西哥人（胃癌发病率低的人群）中IM的低发生率，与瑞典人（胃癌发病率中等）中IM的中等发生率以及日本人（胃癌发病率高）中IM的高发生率形成对比。在不同地理区域记录的这些发现有力地支持了这样一种观点，即IM是一种由环境因素诱发并与胃癌发生相关的病变。
