Leventhal A G, Hirsch H V
J Comp Neurol. 1983 Feb 10;214(1):59-71. doi: 10.1002/cne.902140106.
We studied the receptive field properties of 206 single units in area 19 of normal cats and 228 single units in area 19 of cats deprived of vision for 9-14 months by monocular lid suture. The ocular dominance of a sample of cells in area 17 of normal cats was studied for comparison. In some of these monocularly deprived animals, we also studied the sizes of relay cells in the parvocellular C laminae of the dorsal lateral geniculate nucleus labeled by electrophoretic injections of horseradish peroxidase into area 19. In area 19 of normal cats, the large majority of cells, regardless of their laminar location and the retinal eccentricity of their receptive fields, were binocular. Most responded equally well to the two eyes. In area 17, (see also Leventhal and Hirsch, '78, '80) but not in area 19, the cells which had the narrowest receptive fields tended to be activated unequally by the two eyes. In area 19 of monocularly deprived cats, virtually all cells (97%), regardless of their laminar location and receptive field eccentricity, responded only to stimulation of the normal eye. Thus, the effects of monocular deprivation upon area 19 are apparently more severe than those reported for area 17. In area 17 significant numbers of neurons in layer 4 can be activated by the deprived eye (Shatz and Stryker, '78). Within the limits of our technique, measurements of relay cells in the parvocellular C laminae labeled by injections into area 19 of deprived cats indicated that cell size in the deprived C laminae was unaffected by the deprivation. In contrast, cells in the deprived A laminae of these cats were severely shrunken. These findings suggest that the types of relay found in the parvocellular C laminae (referred to collectively as W-cells) are not affected by visual deprivation as severely as are the X- and Y-cells in the A laminae. Since laminar location and receptive field width are related to binocularity in area 17 but not in area 19 and the sizes of relay cells in the parvocellular C laminae (see also Hickey, '80) are not seriously affected by monocular deprivation, it is suggested that binocular interactions in area 19 are mainly determined by connections among cortical cells.
我们研究了正常猫19区的206个单神经元以及通过单眼眼睑缝合剥夺视觉9 - 14个月的猫19区的228个单神经元的感受野特性。为作比较，还研究了正常猫17区的一组细胞的眼优势。在一些单眼剥夺的动物中，我们还通过将辣根过氧化物酶电泳注入19区，研究了背外侧膝状核小细胞C层中被标记的中继细胞的大小。在正常猫的19区，绝大多数细胞，无论其在层中的位置以及其感受野的视网膜离心率如何，都是双眼性的。大多数细胞对两只眼睛的反应同样良好。在17区（另见Leventhal和Hirsch，1978年、1980年），但在19区并非如此，具有最窄感受野的细胞倾向于被两只眼睛不均衡地激活。在单眼剥夺的猫的19区，实际上所有细胞（97%），无论其在层中的位置和感受野离心率如何，仅对正常眼的刺激有反应。因此，单眼剥夺对19区的影响显然比报道的对17区的影响更严重。在17区，第4层中有相当数量的神经元可被剥夺的眼睛激活（Shatz和Stryker，1978年）。在我们的技术范围内，对通过注入剥夺猫的19区而被标记的小细胞C层中的中继细胞的测量表明，剥夺的C层中的细胞大小不受剥夺的影响。相比之下，这些猫的被剥夺的A层中的细胞严重萎缩。这些发现表明，小细胞C层中发现的中继类型（统称为W细胞）不像A层中的X细胞和Y细胞那样受到视觉剥夺的严重影响。由于层位置和感受野宽度在17区与双眼性有关，但在19区并非如此，并且小细胞C层中的中继细胞大小（另见Hickey，1980年）不受单眼剥夺的严重影响，因此表明19区中的双眼相互作用主要由皮质细胞之间的连接决定。
