Bipolar and Depressive Disorders Unit, Hospìtal Clinic de Barcelona, c. Villarroel, 170, 08036 Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Psychiatry Department, Institut d'Investigació Biomèdica-Sant Pau (IIBSANT PAU), Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Catalonia, Spain.
Bipolar and Depressive Disorders Unit, Hospìtal Clinic de Barcelona, c. Villarroel, 170, 08036 Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), c. Villarroel, 170, 08036 Barcelona, Spain; Institute of Neurosciences (UBNeuro), Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain.
J Affect Disord. 2024 Mar 15;349:210-216. doi: 10.1016/j.jad.2024.01.012. Epub 2024 Jan 6.
The aim of this study is to evaluate the discrepancy between objective cognitive measures and cognitive subjective complaints in a sample of euthymic patients with bipolar disorder (BD).
One hundred and sixteen participants (83 euthymic patients with BD and 33 healthy controls) were enrolled for this study. Patients were assessed with a comprehensive neuropsychological battery and they also reported their subjective cognitive complaints with the Cognitive Complaints in Bipolar Disorder Rating Scale (COBRA). The discrepancy between objective and subjective data was calculated using a novel methodology proposed in a previous study (Miskowiak, 2016). Statistical analyses included Pearson correlations and multiple linear regression.
Higher number of previous depressive episodes was identified as one variable associated with the global sensitivity composite score (Beta = 0.25; t = 2.1; p = 0.04) and with the verbal learning and memory sensitivity score (Beta = 0.26; t = 2.16; p = 0.03). That is, patients with more previous depressive episodes tend to over-report cognitive complaints. In contrast, higher number of previous hospitalizations was associated with stoicism in the global total score (Beta = -0.27; t = -2.24: p = 0.029) and in the domain of attention/processing speed (Beta = -0.34; t = -2.52; p = 0.016), indicating patients with more hospitalizations tend to report less cognitive complaints.
Our study identified some factors that might help to explain the discrepancy between objective and subjective cognitive measures in BD, including number of previous depressive episodes and number of previous hospitalizations. This highlights the need of the combined use of both types of cognitive measures to make an accurate assessment of cognitive dysfunctions and their effective treatment.
本研究旨在评估躁郁症患者（BD）样本中客观认知测量与认知主观抱怨之间的差异。
本研究纳入了 116 名参与者（83 名躁郁症患者和 33 名健康对照组）。患者接受了全面的神经心理学测试，并用双相障碍认知抱怨量表（COBRA）报告他们的主观认知抱怨。使用之前研究中提出的新方法（Miskowiak，2016）计算客观和主观数据之间的差异。统计分析包括皮尔逊相关和多元线性回归。
更多的既往抑郁发作次数被确定为与全局敏感综合评分（Beta=0.25；t=2.1；p=0.04）和言语学习和记忆敏感性评分（Beta=0.26；t=2.16；p=0.03）相关的一个变量。也就是说，有更多既往抑郁发作的患者往往会过度报告认知抱怨。相比之下，更多的既往住院次数与全局总分（Beta=-0.27；t=-2.24；p=0.029）和注意力/处理速度领域（Beta=-0.34；t=-2.52；p=0.016）的坚忍性相关，表明住院次数较多的患者往往报告较少的认知抱怨。
我们的研究确定了一些可能有助于解释躁郁症中客观和主观认知测量之间差异的因素，包括既往抑郁发作次数和既往住院次数。这强调了需要结合使用这两种类型的认知测量来准确评估认知功能障碍及其有效治疗。
