Abramova Olga, Zorkina Yana, Goncharov Dmitry, Abbazova Evgenia, Baranets Marina, Berdalin Alexander, Ushakova Valeriya, Zakurazhnaya Valeria, Morozova Irina, Ochneva Alexandra, Pavlov Konstantin, Andreyuk Denis, Kostyuk Georgy, Morozova Anna
Mental-Health Clinic No. 1 Named After N.A. Alexeev of Moscow Healthcare Department, Zagorodnoe Highway 2, 115191, Moscow, Russia.
Department of Basic and Applied Neurobiology, V. Serbsky Federal Medical Research Centre of Psychiatry and Narcology, Kropotkinsky Per. 23, 119034, Moscow, Russia.
Parasitol Res. 2025 May 21;124(5):53. doi: 10.1007/s00436-025-08498-w.
Some studies suggest that Toxoplasma gondii infection may increase the risk of developing schizophrenia. Determining changes in blood biomarker concentrations may provide new insights into the underlying mechanisms associated with Toxoplasma gondii infection in schizophrenia. The aim of the study was to evaluate the concentrations of several serum neurobiological and immune parameters and to identify changes in their concentrations that could potentially be indicators of psychopathologic changes in infection. The concentration of biomarkers was determined in serum from patients with schizophrenia (uninfected n = 50, infected n = 30) and from mentally healthy volunteers (uninfected n = 51, infected n = 29) using multiplex analysis. A number of psychometric scales have been applied to assess the cognitive functioning. No significant associations were between schizophrenia and Toxoplasma gondii infection (p = 0.54; OR = 1.18; 95% CI = 0.69-2.01). However, infected patients with schizophrenia had more severe cognitive impairment compared to uninfected schizophrenia patients (PDQ-20). The group of biomarkers has been identified whose concentration changes were observed only between Toxoplasma gondii-infected healthy individuals and individuals with schizophrenia (neurobiological indicators KLK6, UCHL1, Amyloid beta 1-42 and neurogranin; anti-inflammatory cytokine IL-10; chemokines IL-8 and MIP-1 beta), but not between uninfected groups. The hypothesis was proposed that it is possible to use these indices as indicators of the development of schizophrenic psychopathology in Toxoplasma gondii infection. The associations of blood biomarker concentrations with IgA and IgM antibody levels (chemokine RANTES) and with schizophrenia symptoms (hormone-like messenger KLK6; chemokines IP-10 and GRO alpha) were found. Toxoplasma gondii reactivation leads to a decrease in negative symptomatology and reduced FGF-21 levels in patients with schizophrenia, and increased CNTF and NGF beta levels compared to the latent form.
一些研究表明，弓形虫感染可能会增加患精神分裂症的风险。确定血液生物标志物浓度的变化可能为精神分裂症中与弓形虫感染相关的潜在机制提供新的见解。本研究的目的是评估几种血清神经生物学和免疫参数的浓度，并确定其浓度变化，这些变化可能是感染中精神病理变化的潜在指标。使用多重分析测定了精神分裂症患者（未感染n = 50，感染n = 30）和心理健康志愿者（未感染n = 51，感染n = 29）血清中生物标志物的浓度。应用了一些心理测量量表来评估认知功能。精神分裂症与弓形虫感染之间无显著关联（p = 0.54；OR = 1.18；95%CI = 0.69 - 2.01）。然而，与未感染的精神分裂症患者相比，感染的精神分裂症患者有更严重的认知障碍（PDQ - 20）。已确定一组生物标志物，其浓度变化仅在弓形虫感染的健康个体和精神分裂症患者之间观察到（神经生物学指标KLK6、UCHL1、淀粉样β1 - 42和神经颗粒素；抗炎细胞因子IL - 10；趋化因子IL - 8和MIP - 1β），但在未感染组之间未观察到。提出了这样的假设，即有可能将这些指标用作弓形虫感染中精神分裂症精神病理学发展的指标。发现了血液生物标志物浓度与IgA和IgM抗体水平（趋化因子RANTES）以及与精神分裂症症状（激素样信使KLK6；趋化因子IP - 10和GROα）之间的关联。与潜伏形式相比，弓形虫再激活导致精神分裂症患者的阴性症状减少、FGF - 21水平降低，以及CNTF和NGFβ水平升高。
